Drug General Information (ID: DDIKCDN6Z3)
  Drug Name Digitoxin Drug Info Sodium sulfate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiarrhythmic Agents Laxatives
  Structure

 Mechanism of Digitoxin-Sodium sulfate Interaction (Severity Level: Minor)
     Complex formation Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Digitoxin Sodium sulfate
      Mechanism Binds to polyvalent cations Polyvalent cations
      Key Mechanism Factor 1
Factor Name Chelation
Factor Description Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
      Mechanism Description
  • Decreased absorption of Sodium sulfate due to formation of complexes caused by Digitoxin 

References
1 Marcus FI "Pharmacokinetic interactions between digoxin and other drugs." J Am Coll Cardiol 5 (1985): a82-90. [PMID: 2985676]
2 McElnay JC, Harron DW, D'Arcy PF, Eagle MR "Interaction of digoxin with antacid constituents." Br Med J 1 (1978): 1554. [PMID: 656806]
3 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.