Drug General Information (ID: DDIKAEJ952)
Drug Name			St. John's Wort		Drug Info		Fospropofol		Drug Info
Drug Type		Natural product				Small molecule
Therapeutic Class		Herbal Products/Antidepressants				Anesthetics

Mechanism of St. John's Wort-Fospropofol Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		St. John's Wort				Fospropofol
Mechanism		Prolong the sedative effect of general anesthetic				General anesthetic
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of St. John's Wort and Fospropofol

Recommended Action
Management		Based on the suspected interaction, it may be appropriate to advise patients to discontinue use of St. John's wort 5 days before surgery.

References
1	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
2	Crowe S, McKeating K "Delayed Emergence and St. John's Wort." Anesthesiology 96 (2002): 1025-7