Details of Drug

Drug General Information (ID: D0698)
Drug Name	Fospropofol
Drug Type	Small molecule
Drug Synonymous	Fospropofol; 258516-89-1; UNII-LZ257RZP7K; [2,6-di(propan-2-yl)phenoxy]methyl dihydrogen phosphate; LZ257RZP7K; Methanol, (2,6-bis(1-methylethyl)phenoxy)-, dihydrogen phosphate; DEA No. 2138; Fospropofol [INN]; GTPL7475; SCHEMBL3821874; CHEMBL1201766; DTXSID50870295; CHEBI:135193; ZINC2519740; DB06716; FT-0727559; Q5473368 Click to Show/Hide
Therapeutic Class	Anesthetics
Structure
Structure	3D Structure		2D Structure
Formula	C13H21O5P
InChI	InChI=1S/C13H21O5P/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16)
InChIKey	QVNNONOFASOXQV-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)(O)O
External Link
	Pubchem ID	3038498
	INTEDE ID	DR0753

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Fospropofol
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 58
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[7], [8], [9], [10], [11], [12]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[14], [9], [10]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[14], [9], [10]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0445		Desflurane	C3H2F6O	42113	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[14], [9], [10]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[14], [9], [10]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[14], [9], [10]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0625		Etomidate	C14H16N2O2	667484	Moderate		Inter Info	[14], [9], [10]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[14], [9], [10]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1183		Opium	NA	NA	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0855		Isoflurane	C3H2ClF5O	3763	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[14], [9], [10]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[14], [9], [10]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[7], [13], [14], [15], [9], [10]
	Additive CNS depression effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1]
D1391		Remimazolam	C21H19BrN4O2	9867812	Major		Inter Info	[1]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[2], [3]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[17], [16], [18]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[17], [16], [18]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[17], [16], [18]
	Additive hypotensive effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[16]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[16]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[16]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[16]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[16]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[16]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[16]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[16]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[21], [22]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[4], [5], [6]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[4], [5], [6]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[4], [5], [6]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[4], [5], [6]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[19], [16], [20]

References
1	US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
2	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
3	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
4	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
5	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
6	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
7	Gill SS, Wright EM, Reilly CS "Pharmacokinetic interaction of propofol and fentanyl: single bolus injection study." Br J Anaesth 65 (1990): 760-5. [PMID: 2265045]
8	IselinChaves IA, Flaishon R, Sebel PS, Howell S, Gan TJ, Sigl J, Ginsberg B, Glass PSA "The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the bispectral index." Anesth Analg 87 (1998): 949-55. [PMID: 9768800]
9	Product Information. Diprivan (propofol). Zeneca Pharmaceuticals, Wilmington, DE.
10	Product Information. Lusedra (fospropofol). Eisai Inc, Teaneck, NJ.
11	Stanski DR, Shafer SL "Quantifying anesthetic drug interaction. Implications for drug dosing." Anesthesiology 83 (1995): 1-5. [PMID: 7604988]
12	Vuyk J, Lim T, Engbers FH, Burm AG, Vletter AA, Bovill JG "The pharmacodynamic interaction of propofol and alfentanil during lower abdominal surgery in women." Anesthesiology 83 (1995): 8-22. [PMID: 7605022]
13	Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, Asada A "Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study." Clin Pharmacol Ther 66 (1999): 110-7. [PMID: 10460064]
14	McClune S, McKay AC, Wright PM, et al "Synergistic interaction between midazolam and propofol." Br J Anaesth 69 (1992): 240-5. [PMID: 1389840]
15	Pavlin DJ, Coda B, Shen DD, et al "Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers." Anesthesiology 84 (1996): 23-37. [PMID: 8572340]
16	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
17	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
18	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
19	Cerner Multum, Inc. "Australian Product Information.".
20	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
21	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
22	Crowe S, McKeating K "Delayed Emergence and St. John's Wort." Anesthesiology 96 (2002): 1025-7

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