Drug General Information (ID: DDIJUEH14A)
Drug Name			Aluminum hydroxide		Drug Info		Potassium citrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antacids				Minerals And Electrolytes
Structure

Mechanism of Aluminum hydroxide-Potassium citrate Interaction (Severity Level: Major)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Aluminum hydroxide				Potassium citrate
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Aluminum hydroxide due to formation of complexes caused by Potassium citrate

Recommended Action
Management		The concomitant use of aluminum- and citrate-containing products should be avoided in renally impaired patients. Some experts also recommend that healthy patients should separate doses of aluminum-containing antacids and citrates by 2 to 3 hours.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".