Drug General Information (ID: DDIJSDBYF5)
Drug Name			Sucralfate		Drug Info		Furosemide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Diuretics
Structure

Mechanism of Sucralfate-Furosemide Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Furosemide
Mechanism		Polyvalent cations				Binds to polyvalent cations
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Sucralfate due to formation of complexes caused by Furosemide

Recommended Action
Management		Oral furosemide and sucralfate doses should be separated by at least 2 hours.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.