Drug General Information (ID: DDIJOVSGRU)
Drug Name			Didanosine		Drug Info		Dasatinib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antineoplastics
Structure

Mechanism of Didanosine-Dasatinib Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Didanosine				Dasatinib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Dasatinib due to altered gastric pH caused by Didanosine

Recommended Action
Management		Patients treated with dasatinib should avoid taking antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or paediatric oral solution) for at least two hours before and two hours after administration of dasatinib.

References
1	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.