Drug General Information (ID: DDIIV1C4MT)
Drug Name			Dinoprostone (topical)		Drug Info		Ergometrine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Prostaglandins				Oxytocics
Structure

Mechanism of Dinoprostone (topical)-Ergometrine Interaction (Severity Level: Major)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Dinoprostone (topical)				Ergometrine
Mechanism		Dinoprostone				Potentiate the uterine contraction effect of dinoprostone
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Dinoprostone (topical) and Ergometrine

Recommended Action
Management		The concomitant use of dinoprostone with other oxytocic agents is considered contraindicated.

References
1	Product Information. Prostin E2 (dinoprostone topical). Pharmacia and Upjohn, Kalamazoo, MI.
2	Product Information. Prostin E2 Suppository (dinoprostone topical). Pharmacia and Upjohn, Kalamazoo, MI.