Drug General Information (ID: DDIIUD4ZL8)
Drug Name			Vibrio cholerae CVD 103-HgR strain live antigen (live)		Drug Info		Cefiderocol		Drug Info
Drug Type		Vaccine				Small molecule
Therapeutic Class		Vaccines				Cephalosporins/Beta-Lactamase Inhibitors

Mechanism of Vibrio cholerae CVD 103-HgR strain live antigen (live)-Cefiderocol Interaction (Severity Level: Major)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Vibrio cholerae CVD 103-HgR strain live antigen (live)				Cefiderocol
Mechanism		Immunomodulatory infective agent				Impairs immunomodulatory bacterial infective agent
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Vibrio cholerae CVD 103-HgR strain live antigen (live) when combined with Cefiderocol

Recommended Action
Management		Live, attenuated cholera vaccine should not be administered during or for at least 14 days after treatment with systemic antibiotics.

References
1	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.