Details of Drug

Details of Drug

 Drug General Information (ID: D0280)
  Drug Name
Cefiderocol
  Drug Type Small molecule
  Drug Synonymous
Cephalosporin, GSK2696266; S-649266
    Click to Show/Hide
  Disease Class GC08: Urinary tract infection; CA00-CA40: Pneumococcal infection; PK80-PK81: Medical/surgical procedure injury; CA40: Pneumonia
  Therapeutic Class Cephalosporins/Beta-Lactamase Inhibitors
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C30H34ClN7O10S2
  InChI 1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
  InChIKey DBPPRLRVDVJOCL-FQRUVTKNSA-N
  Canonical SMILES CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4(CCCC4)CCNC(=O)C5=C(C(=C(C=C5)O)O)Cl)C(=O)[O-]
  External Link
Pubchem ID 77843966
CAS Number 1225208-94-5
TTD ID D0Q7MA

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM002  Altered intestinal flora
BM011  Transporter induction
BM022  CYP450 enzyme induction
BM050  Increased risk of bleeding
BM069  Increased risk of lowers seizure threshold
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Cefiderocol
      Affected gastrointestinal absorption
   Altered intestinal flora Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1094
 
Mycophenolate mofetil
 
C23H31NO7
 
5281078 
Moderate    Inter Info   
[63], [64]
D1095
 
Mycophenolic acid
 
C17H20O6
 
446541 
Moderate    Inter Info   
[63], [64]
      Affected cellular transport
   Transporter induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Major    Inter Info   
[25], [26]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme induction Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Major    Inter Info   
[3], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Major    Inter Info   
[21], [22], [23]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Major    Inter Info   
[3], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Major    Inter Info   
[3], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1203
 
Oxycodone
 
C18H21NO4
 
5284603 
Major    Inter Info   
[3], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0008
 
Acalabrutinib
 
C26H23N7O2
 
71226662 
Moderate    Inter Info   
[37]
D0129
 
Avapritinib
 
C26H27FN10
 
118023034 
Moderate    Inter Info   
[17], [43]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[62]
D1388
 
Relugolix
 
C29H27F2N7O5S
 
10348973 
Moderate    Inter Info   
[70]
D1409
 
Ripretinib
 
C24H21BrFN5O2
 
71584930 
Moderate    Inter Info   
[16], [71]
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[40], [41], [42]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[40], [41], [42]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[40], [41], [42]
   Increased risk of lowers seizure threshold Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[27], [28], [29], [30], [31]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[27], [28], [29], [30], [31]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[32], [14], [13], [33]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[38], [39]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[16], [17]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[50], [51], [52], [53], [54], [55], [56], [57]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[59], [60], [61]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[68], [69], [17]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[68], [69], [17]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[17], [34], [35]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[36]
   Attenuated pharmacological effects (Unspecific) Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[44], [45], [46]
D0606
 
Estradiol
 
C18H24O2
 
5757 
Moderate    Inter Info   
[47], [48], [49]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[47], [48], [49]
D1817
 
Indium In-111 oxyquinoline
 
C27H18InN3O3
 
16685037 
Moderate    Inter Info   
[58]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[47], [48], [49]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[65], [66], [67]
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