Drug General Information (ID: DDIIRPKAME)
Drug Name			Vasopressin		Drug Info		Ifosfamide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Antineoplastics
Structure

Mechanism of Vasopressin-Ifosfamide Interaction (Severity Level: Moderate)
Increased risk of hyponatremia Click to Show/Hide Mechanism Graph
Drug Name		Vasopressin				Ifosfamide
Mechanism		Hyponatremia				Hyponatremia
Key Mechanism Factor 1
		Factor Name		Hyponatremia
		Factor Description		Hyponatremia is a condition in which the amount of sodium in the blood is lower than normal. Symptoms of hyponatremia may include: nausea and vomiting, fatigue, headache or confusion, muscle cramps, weakness, irritability and restlessness.
Mechanism Description		Increased risk of hyponatremia by the combination of Vasopressin and Ifosfamide

Recommended Action
Management		Caution is advised when vasopressin or desmopressin is used in combination with drugs that can cause fluid retention or SIADH. Some authorities recommend adjusting vasopressin dosage as needed. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly. Patients should be advised to seek medical attention if they develop signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, headache, malaise, lethargy, irritability, difficulty concentrating, memory impairment, confusion, weakness, muscle spasm, unsteadiness (which may lead to falls), anuria, and weight gain. Severe hyponatremia can be life-threatening if it is not promptly diagnosed and treated therefore, early treatment is important to help prevent progression to seizures, coma, respiratory arrest, and death.

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