Drug General Information (ID: DDIILERXWG)
Drug Name			Ranitidine		Drug Info		Fosamprenavir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiulcer Agents				Anti-Hiv Agents
Structure

Mechanism of Ranitidine-Fosamprenavir Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ranitidine				Fosamprenavir
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Fosamprenavir due to altered gastric pH caused by Ranitidine

Recommended Action
Management		Caution is advised if fosamprenavir is prescribed with H2-receptor antagonists or proton pump inhibitors. Antiretroviral response should be monitored closely during coadministration.

References
1	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.