Drug General Information (ID: DDII2X7JYA)
Drug Name			Diclofenamide		Drug Info		Indium In-111 pentetate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Ophthalmic Glaucoma Agents				Diagnostic Radiopharmaceuticals
Structure

Mechanism of Diclofenamide-Indium In-111 pentetate Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Diclofenamide				Indium In-111 pentetate
Mechanism		Cause false-positive cisternogram results with indium In-111 pentetate				Indium In-111 pentetate
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Indium In-111 pentetate by Diclofenamide

Recommended Action
Management		Clinicians should be aware of the possibility of a diagnostic interference.

References
1	Mathias CJ, Wang S, Waters DJ, Turek JJ, Low PS, Green MA. Indium-111-DTPA-folate as a potential folate-receptor-targeted radiopharmaceutical.?J Nucl Med. 1998;39(9):1579-1585. [PMID: 9744347]