Drug General Information (ID: DDIHYDE95M)
Drug Name			Ethambutol		Drug Info		Aluminum hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antitubercular Agents				Antacids
Structure

Mechanism of Ethambutol-Aluminum hydroxide Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ethambutol				Aluminum hydroxide
Mechanism		Ethambutol				Decrease absorption of ethambutol
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Ethambutol caused by Aluminum hydroxide

Recommended Action
Management		To minimize the potential for interaction, ethambutol labeling recommends that aluminum hydroxide-containing antacids be avoided for at least 4 hours following ethambutol administration.

References
1	Mattila MJ, Linnoila M, Seppala T, Koskinen R "Effect of aluminium hydroxide and glycopyrrhonium on the absorption of ethambutol and alcohol in man." Br J Clin Pharmacol 5 (1978): 161-6. [PMID: 619949]
2	Peloquin CA, Bulpitt AE, Jaresko GS, Jelliffe RW, Childs JM, Nix DE "Pharmacokinetics of ethambutol under fasting conditions, with food, and with antacids." Antimicrob Agents Chemother 43 (1999): 568-72. [PMID: 10049268]
3	Product Information. Myambutol (ethambutol). Lederle Laboratories, Wayne, NJ.