Drug General Information (ID: DDIHWC0T68)
Drug Name			Ezetimibe		Drug Info		Flax seed		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antihyperammonia Agents				Herbal Products

Mechanism of Ezetimibe-Flax seed Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ezetimibe				Flax seed
Mechanism		Ezetimibe				Absorption decreased by ezetimibe
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Flax seed caused by Ezetimibe

Recommended Action
Management		Until further information is available, clinical or laboratory monitoring of the expected therapeutic benefits of flaxseed oil is recommended when ezetimibe is co-administered with flaxseed oil.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Zetia (ezetimibe). Schering-Plough Corporation, Kenilworth, NJ.