Details of Drug

Details of Drug

 Drug General Information (ID: D0631)
  Drug Name
Ezetimibe
  Drug Type Small molecule
  Drug Synonymous
Ezedoc; Ezetimib; Ezetrol; Zetia; Zient; Essex brand of ezetimibe; MSD brand of ezetimibe; Merck brand of ezetimibe; SCH58235; Sch 58235; Ezetimibe [USAN:INN]; Inegy (TN); MK-0653; SCH-58235; Schering-Plough brand of ezetimibe; Vytorin (TN); Zetia (TN); Zetia , Ezetrol, Ezetimibe; Ezetimibe (JAN/USAN/INN); (-)-Sch 58235; (1-(4-fluorophenyl)-(3R)-(3-(4-fluorophenyl)-(3S)-hydroxypropyl)-(4S)-(4-hydroxyphenyl)-2-azetidinone); (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3R,4S)-1-(p-Fluorophenyl)-3-((3S)-3-(p-fluorophenyl)-3-hydroxypropyl)-4-(p-hydroxyphenyl)-2-azetidinone; 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-(4-hydroxyphenyl)-2-azetidione; 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone
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  Disease Class 5C80: Hyper-lipoproteinaemia
  Therapeutic Class Antihyperammonia Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C24H21F2NO3
  InChI 1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
  InChIKey OLNTVTPDXPETLC-XPWALMASSA-N
  Canonical SMILES C1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)O)O
  External Link
Pubchem ID 150311
CAS Number 163222-33-1
CHEBI ID 49040
TTD ID D09LWS
INTEDE ID DR0677
VARIDT ID DR00140

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
BM009  Altered absorption (Unspecific)
BM010  Transporter inhibition
BM011  Transporter induction
BM022  CYP450 enzyme induction
BM023  UGT induction
  Relation Graph
 Full list of drugs interacting with Ezetimibe
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0663
 
Flax seed
 
NA
 
NA
Moderate    Inter Info   
[7], [1], [11]
      Affected cellular transport
   Transporter inhibition Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0425
 
Darolutamide
 
C19H19ClN6O2
 
67171867 
Moderate    Inter Info   
[1], [3]
D0558
 
Elexacaftor
 
C26H34F3N7O4S
 
134587348 
Moderate    Inter Info   
[4], [5], [6]
D0568
 
Enasidenib
 
C19H17F6N7O
 
89683805 
Moderate    Inter Info   
[7], [8]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[1], [9]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[7], [1], [10]
D0700
 
Fostemsavir
 
C25H26N7O8P
 
11319217 
Moderate    Inter Info   
[12]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[1]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[13], [14]
   Transporter induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[1], [2]
      Affected intra/extra-hepatic metabolism
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
3 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
4 Product Information. Cozaar (losartan). Merck &amp Co, Inc, West Point, PA.
5 Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
6 Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
7 Cerner Multum, Inc. "Australian Product Information.".
8 Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
9 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
10 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
11 Product Information. Zetia (ezetimibe). Schering-Plough Corporation, Kenilworth, NJ.
12 Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
13 Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
14 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.