Drug General Information (ID: DDIHQ3C4L8)
Drug Name			Sulfadoxine		Drug Info		Typhoid vaccine (live)		Drug Info
Drug Type		Small molecule				Vaccine
Therapeutic Class		Antimalarial Agents				Vaccine

Mechanism of Sulfadoxine-Typhoid vaccine (live) Interaction (Severity Level: Minor)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Sulfadoxine				Typhoid vaccine (live)
Mechanism		Impairs immunomodulatory bacterial infective agent				Immunomodulatory infective agent
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Typhoid vaccine (live) when combined with Sulfadoxine

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Kollaritsch H, Que JU, Kunz C, Wiedermann G, Herzog C, Cryz SJ Jr "Safety and immunogenicity of live oral cholera and typhoid vaccines administered alone or in combination with antimalarial drugs, oral polio vaccine, or yellow fever vaccine." J Infect Dis 175 (1997): 871-5. [PMID: 9086143]
3	Product Information. Vivotif Berna (typhoid vaccine, live) Crucell Vaccine Inc, Coral Gables, FL.