Drug General Information (ID: DDIHOY5LF4)
  Drug Name Ethanol Drug Info Diethylpropion Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Analgesics Cns Stimulants
  Structure

 Mechanism of Ethanol-Diethylpropion Interaction (Severity Level: Moderate)
     Additive CNS depression effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Ethanol Diethylpropion
      Mechanism CNS depression effects CNS depression effects
      Key Mechanism Factor 1
Factor Name CNS depression effects
Factor Description CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
      Mechanism Description
  • Additive CNS depression effects by the combination of Ethanol and Diethylpropion 

Recommended Action
      Management Concomitant use of centrally-acting appetite suppressants and alcohol should be avoided if possible, especially in patients with a history of cardiovascular disease. Patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References
1 Product Information. Suprenza (phentermine). Akrimax Pharmaceuticals, Cranford, NJ.
2 Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
3 Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.