Drug General Information (ID: DDIGZCLPMS)
Drug Name			Trifluoperazine		Drug Info		Magnesium hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antipsychotic Agents				Antacids/Laxatives
Structure

Mechanism of Trifluoperazine-Magnesium hydroxide Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Trifluoperazine				Magnesium hydroxide
Mechanism 1		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Magnesium hydroxide due to altered gastric pH caused by Trifluoperazine
Increased risk of ventricular arrhythmias Click to Show/Hide Mechanism Graph
Drug Name		Trifluoperazine				Magnesium hydroxide
Mechanism 2		Prolong QT interval				Electrolyte disturbances
Key Mechanism Factor 2
		Factor Name		Ventricular arrhythmias
		Factor Description		Ventricular arrhythmias are abnormal heart rhythms that cause your heart's lower chambers to pump blood instead of pumping it. This can limit or stop your heart from supplying blood to your body. While some of these arrhythmias are harmless and do not cause symptoms, others can have serious, even fatal, effects on your body.
Mechanism Description		Increased risk of ventricular arrhythmias by the combination of Trifluoperazine and Magnesium hydroxide

Recommended Action
Management		Patients treated with drugs that prolong the QT interval should exercise caution when self-medicating with laxatives including magnesium hydroxide. The recommended dosage and duration of use should not be exceeded. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.

References
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