Drug General Information (ID: DDIGQZUDKR)
Drug Name			Propranolol		Drug Info		Zileuton		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antianxiety Agents				Antiinflammatory Agents
Structure

Mechanism of Propranolol-Zileuton Interaction (Severity Level: Moderate)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Propranolol				Zileuton
Mechanism		Propranolol				Inhibit the hepatic metabolism of propranolol
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Propranolol caused by Zileuton

Recommended Action
Management		If zileuton and propranolol must be given concomitantly, the patient should be observed closely for altered propranolol effects and the dose adjusted accordingly. Patients should be advised to notify their physician if they experience syncope,slow pulse, irregular heartbeat, dizziness, or shortness of breath.

References
1	Product Information. Zylo Filmtab (zileuton). Abbott Pharmaceutical, Abbott Park, IL.