Drug General Information (ID: DDIGHBLRUW)
Drug Name			Goserelin		Drug Info		Halofantrine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Antimalarial Agents
Structure

Mechanism of Goserelin-Halofantrine Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Goserelin				Halofantrine
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Goserelin and Halofantrine

Recommended Action
Management		Coadministration of halofantrine with other drugs that can prolong the QT interval is considered contraindicated.

References
1	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
2	Canadian Pharmacists Association.
3	Cerner Multum, Inc. "Australian Product Information.".
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
6	Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6. [PMID: 8096959]
7	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
8	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
9	Sudden death in a traveler following halofantrine administration--Togo, 2000. MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179. [PMID: 11393488]