Details of Drug

Drug General Information (ID: D0749)
Drug Name	Halofantrine
Drug Type	Small molecule
Drug Synonymous	Halfan; Halofantrino; HALOFANTRINE HYDROCHLORIDE; Halofantrine HCl; Halofantrine Hydrochloride [USAN]; Halofantrine [USAN]; Halofantrino [Spanish]; WR 171669; Dl-WR 171669; Halfan (TN); Halofantrine hydrochloride (USAN); WR 171,699; WR-171669; WR-171699; SK&F-102866; WR-171,669; (+-)-Halofantrine hydrochloride; (1)-Halofantrine; 1,3-Dichloro-.alpha.-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrene-methanol; 1,3-Dichloro-.alpha.-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenathrenemethanol; 1,3-Dichloro-6-trifluoromethyl-9-(3-(dibutylamino)-1-hydroxypropyl)phenanthrene HCl; 1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-9-phenanthrenemethanol hydrochloride; 1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)phenanthren-1-methanol hydrochloride; 1-(1,3-Dichloro-6-trifluoromethyl-9-phenanthryl)-3-(di-n-butylamino)propanol hydrochloride; 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl; 3-(Dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-ol hydrochloride; 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol; 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol hydrochloride; 9-(3-(dibutylamino)-1-hydroxypropyl)-1,3-dichloro-6-(trifluoromethyl)phenanthrene hydrochloride; 9-Phenanthrenemethanol, 1,3-dichloro-.alpha.-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-(1); 9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, hydrochloride; 9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-,hydrochloride Click to Show/Hide
Disease Class	1F40-1F45: Malaria
Therapeutic Class	Antimalarial Agents
Structure
Structure	3D Structure		2D Structure
Formula	C26H30Cl2F3NO
InChI	1S/C26H30Cl2F3NO/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3
InChIKey	FOHHNHSLJDZUGQ-UHFFFAOYSA-N
Canonical SMILES	CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O
External Link
	Pubchem ID	37393
	CAS Number	69756-53-2
	CHEBI ID	94392
	TTD ID	D07MVK
	INTEDE ID	DR0799
	VARIDT ID	DR00770

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Halofantrine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[123], [30], [124]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 50
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[17], [12], [14]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[9], [18], [17], [12], [14]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[9], [18], [17], [12], [14]
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[9], [18], [17], [12], [14]
D0367		Clotrimazole	C22H17ClN2	2812	Major		Inter Info	[9], [18], [17], [12], [14]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[9], [18], [17], [12], [14]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[9], [18], [17], [12], [14]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[17], [12], [14]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[9], [18], [17], [12], [14]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[9], [18], [17], [12], [14]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[9], [18], [17], [12], [14]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[9], [18], [17], [12], [14]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[17], [12], [14]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[9], [18], [17], [12], [14]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[9], [18], [17], [12], [14]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[17], [12], [14]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[9], [18], [17], [12], [14]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[9], [18], [17], [12], [14]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[9], [18], [17], [12], [14]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[9], [18], [17], [12], [14]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[9], [18], [17], [12], [14]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[9], [18], [17], [12], [14]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[17], [12], [14]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[17], [12], [14]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[9], [18], [14], [34]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[17], [12], [14]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[17], [12], [14]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[9], [18], [17], [12], [14]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[9], [18], [17], [12], [14]
D0858		Isoniazid	C6H7N3O	3767	Major		Inter Info	[9], [18], [17], [12], [14]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[9], [18], [17], [12], [14]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[9], [18], [17], [12], [14]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[9], [18], [17], [12], [14]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[9], [18], [17], [12], [14]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[9], [18], [17], [12], [14]
D1714		Zafirlukast	C31H33N3O6S	5717	Major		Inter Info	[9], [18], [17], [12], [14]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[77]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[91], [92]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[11], [2], [93], [94], [92], [95]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[96], [97]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[105]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[11], [2], [106], [107], [108], [109], [110], [111]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[117], [118]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[121]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[122]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[134]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[151], [152], [153]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[102], [84], [154], [155]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[165], [166], [84]
	CYP450 enzyme induction					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[2], [75], [76]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[115]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[2], [116]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[11], [119]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[120]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[125]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[126], [127]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[11], [2], [128]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [129]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[11], [2], [135], [136]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[148], [149]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[11], [2], [128]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[156], [157], [158], [159], [160]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[156], [157], [158], [159], [160]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[130], [131]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[130], [131]
Pharmacodynamic additive effects
	Increased risk of prolong QT interval					Drug Num: 166
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[10], [11], [2], [19], [20], [21], [22]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[11], [14], [15]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[11], [14], [15]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[11], [14], [15]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[11], [14], [15]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[11], [14], [15]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[10], [11], [2], [23]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[11], [14], [15]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[11], [14], [15]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[11], [14], [15]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[11], [14], [15]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[11], [14], [15]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[11], [14], [15]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[11], [14], [15]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[12], [27], [14]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[28], [29], [30]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[11], [14], [15]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[11], [14], [15]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[11], [14], [15]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[11], [14], [15]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[11], [14], [15]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[9], [39], [13], [14], [15], [16]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[11], [14], [15]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[10], [11], [2], [40]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[11], [14], [15]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[41], [42], [43], [44], [45], [46], [47], [48]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[49], [50]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[11], [14], [15]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[11], [14], [15]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[9], [10], [11], [2], [12], [13], [14], [15], [16]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[11], [2], [98]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[132], [133]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[11], [2], [137]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[138], [139], [140], [141], [142], [143], [144], [145], [146], [147]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[11], [161], [162], [163]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[10], [11], [164]
	Increased risk of ventricular arrhythmias					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[10], [11], [2], [24], [22]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[2], [25], [26]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Major		Inter Info	[31], [32], [33]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Major		Inter Info	[31], [32], [33]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[11], [35]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[36], [37], [38]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[36], [37], [38]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[36], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [37], [69], [70], [71], [72], [38], [73], [74]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[36], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [99], [100], [63], [64], [65], [66], [67], [101], [68], [37], [69], [70], [71], [72], [38], [73], [74]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[10], [11], [2], [102], [103], [104]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[36], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [99], [100], [63], [64], [65], [66], [67], [101], [68], [37], [69], [70], [71], [72], [38], [73], [74]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[10], [11], [2], [112], [113], [114]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[10], [11], [2], [112], [113], [114]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[11], [2], [114]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[10], [11], [2], [112], [113], [114]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[36], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [99], [100], [63], [64], [65], [66], [67], [101], [68], [37], [69], [70], [71], [72], [38], [73], [74]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[11], [2], [114]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[99], [69], [72]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[10], [11], [2], [112], [113], [114]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[10], [11], [2], [112], [113], [114]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[10], [11], [2], [112], [113], [114]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[36], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [99], [100], [63], [64], [65], [66], [67], [101], [68], [37], [69], [70], [71], [72], [38], [73], [74]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[99], [69], [72]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[11], [2], [114]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[99], [69], [72]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[10], [11], [2], [112], [113], [114]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[10], [11], [2], [102], [103], [104]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[55], [61], [66]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[36], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [99], [100], [63], [64], [65], [66], [67], [101], [68], [37], [69], [70], [71], [72], [38], [73], [74]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[11], [2], [150]

References
1	Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
4	Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
5	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
6	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
7	Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
8	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
9	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
10	Canadian Pharmacists Association.
11	Cerner Multum, Inc. "Australian Product Information.".
12	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
13	Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6. [PMID: 8096959]
14	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
15	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
16	Sudden death in a traveler following halofantrine administration--Togo, 2000. MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179. [PMID: 11393488]
17	Charbit B, Becquemont L, Lepere B, Peytavin G, Funck-Bretano C "Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine." Clin Pharmacol Ther 72 (2002): 514-23. [PMID: 12426515]
18	Baune B, Flinois JP, Furlan V, et al. "Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5." J Pharm Pharmacol 51 (1999): 419-26. [PMID: 10385214]
19	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
20	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
21	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
22	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
23	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
24	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
25	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
26	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
27	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
28	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
29	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
30	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
31	Hill AG, Parry BR "Hypokalaemia following bowel cleansing with sodium phosphate." N Z Med J 109 (1996): 347. [PMID: 8862361]
32	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
33	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
34	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
35	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
36	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
37	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
38	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
39	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
40	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
41	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
42	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
43	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
44	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
45	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
46	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
47	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
48	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
49	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
50	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
51	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
52	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
53	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
54	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
55	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
56	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
57	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
58	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
59	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
60	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
61	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
62	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
63	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
64	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
65	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
66	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
67	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
68	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
69	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
70	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
71	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
72	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
73	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
74	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
75	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
76	Wakelee HA, Takimoto CH, Lopez-Anaya A, et al. "The effect of bexarotene on atorvastatin pharmacokinetics: results from a phase I trial of bexarotene plus chemotherapy in patients with advanced non-small cell lung cancer." Cancer Chemother Pharmacol 69 (2012): 563-71. [PMID: 22057855]
77	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
78	Caraco Y, Sheller J, Wood AJJ "Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects." J Pharmacol Exp Ther 290 (1999): 413-22. [PMID: 10381807]
79	Caraco Y, Sheller J, Wood JJ "Pharmacogenetic determination of the effects of codeine and prediction of drug interactions." J Pharmacol Exp Ther 278 (1996): 1165-74. [PMID: 8819499]
80	Desmeules J, Dayer P, Gascon MP, Magistris M "Impact of genetic and environmental factors on codeine analgesia." Clin Pharmacol Ther 45 (1989): 122. [PMID: 1782973]
81	Desmeules J, Gascon MP, Dayer P, Magistris M "Impact of environmental and genetic factors on codeine analgesia." Eur J Clin Pharmacol 41 (1991): 23-6. [PMID: 1782973]
82	Hersh EV, Moore PA "Drug interactions in dentistry: the importance of knowing your CYPs." J Am Dent Assoc 135 (2004): 298-311. [PMID: 15058617]
83	Poulsen L, Brosen K, Srendt-Nielsen L, Gram LF, Elbaek K, Sindrup SH "Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects." Eur J Clin Pharmacol 51 (1996): 289-95. [PMID: 9010701]
84	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
85	Sindrup SH, Arendt-Nielsen L, Brosen K, et al "The effect of quinidine on the analgesic effect of codeine." Eur J Clin Pharmacol 42 (1992): 587-92. [PMID: 1623898]
86	Sindrup SH, Brosen K, Bjerring P, et al. "Codeine increases pain threshold to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine." Clin Pharmacol Ther 49 (1991): 686-93. [PMID: 2249379]
87	Sindrup SH, Hofmann U, Asmussen J, Mikus G, Brosen K, Nielsen F, Ingwersen SH, Broen Christensen C "Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake." Eur J Clin Pharmacol 49 (1996): 503-9. [PMID: 8706777]
88	Thorn CF, Klein TE, Altman RB "Codeine and morphine pathway." Pharmacogenet Genomics 19 (2009): 556-8. [PMID: 19512957]
89	Vevelstad M, Pettersen S, Tallaksen C, Brors O "O-demethylation of codeine to morphine inhibited by low-dose levomepromazine." Eur J Clin Pharmacol 65 (2009): 795-801. [PMID: 19308365]
90	Zhou SF "Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II." Clin Pharmacokinet 48 (2009): 761-804. [PMID: 19902987]
91	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
92	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
93	Funck-Brentano C, Jacqz-Aigrain E, Leenhardt A, Roux A, Poirier JM, Jaillon P "Influence of amiodarone on genetically determined drug metabolism in humans." Clin Pharmacol Ther 50 (1991): 259-66. [PMID: 1914360]
94	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
95	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
96	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
97	Skinner MH, Kuan HY, Pan A, et al. "Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers." Clin Pharmacol Ther 73 (2003): 170-7. [PMID: 12621382]
98	Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
99	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
100	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
101	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
102	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
103	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
104	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
105	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
106	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
107	Kane JM, Carson WH, Saha AR, et al. "Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder." J Clin Psychiatry 63 (2002): 763-71. [PMID: 12363115]
108	Keck PE Jr, Marcus R, Tourkodimitris S, et al. "A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania." Am J Psychiatry 160 (2003): 1651-8. [PMID: 12944341]
109	Nelson S, Leung JG "Torsades de Pointes After Administration of Low-Dose Aripiprazole (February)." Ann Pharmacother (2013):. [PMID: 23362038]
110	Pigott TA, Carson WH, Saha AR, Torbeyns AF, Stock EG, Ingenito GG "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study." J Clin Psychiatry 64 (2003): 1048-56. [PMID: 14628980]
111	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
112	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
113	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
114	Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
115	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
116	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
117	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
118	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
119	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
120	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
121	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
122	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
123	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
124	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
125	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
126	Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA.
127	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
128	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
129	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
130	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
131	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
132	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
133	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
134	Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
135	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
136	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
137	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
138	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
139	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
140	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
141	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
142	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
143	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
144	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
145	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
146	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
147	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
148	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
149	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
150	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
151	Edeki TI, He HB, Wood AJJ "Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops: potential for oral-ophthalmic drug interaction." JAMA 274 (1995): 1611-3. [PMID: 7474246]
152	Fraunfelder FT, Fraunfelder FW Randall JA "Drug-Induced Ocular Side Effects 5th" Boston, MA: Butterworth-Heinemann (2001):.
153	Lewis RV, Lennard MS, Jackson PR, Tucker GT, Ramsay LE, Woods HF "Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics." Br J Clin Pharmacol 19 (1985): 329-33. [PMID: 2859048]
154	Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8. [PMID: 10811561]
155	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4. [PMID: 9839763]
156	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
157	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
158	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
159	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
160	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
161	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
162	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
163	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
164	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
165	Brynne N, Svanstrom C, AbergWistedt A, Hallen B, Bertilsson L "Fluoxetine inhibits the metabolism of tolterodin-pharmacokinetic implications and proposed clinical relevance." Br J Clin Pharmacol 48 (1999): 553-63. [PMID: 10583026]
166	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.

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