Drug General Information (ID: DDIGFBPLAM)
Drug Name			Thiabendazole		Drug Info		Aminophylline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antinematodal Agents				Bronchodilators
Structure

Mechanism of Thiabendazole-Aminophylline Interaction (Severity Level: Moderate)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Thiabendazole				Aminophylline
Mechanism		Inhibition metabolism of methylxanthine				Methylxanthine
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Aminophylline caused by Thiabendazole

Recommended Action
Management		Clinical monitoring of patient response and tolerance and serum theophylline levels is recommended. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians. The theophylline dosage may require reduction or alternatives agents could be considered during thiabenzole therapy.

References
1	Lew G, Murray WE, Lane JR, Haeger E "Theophylline-thiabendazole drug interaction." Clin Pharm 8 (1989): 225-7. [PMID: 2706897]
2	Schneider D, Gannon R, Sweeney K, Shore E "Theophylline and antiparasitic drug interactions: a case report and study of the influence of thiabendazole and mebendazole on theophylline pharmacokinetics in adult." Chest 97 (1990): 84-7. [PMID: 2295264]
3	Sugar AM, Kearns PJ, Haulk AA, Rushing JL "Possible thiabendazole-induced theophylline toxicity." Am Rev Respir Dis 122 (1980): 501-3. [PMID: 7416626]
4	Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50. [PMID: 1709398]