Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIFT59WO6)
  Drug Name Gemcitabine Drug Info Cedazuridine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antineoplastics Antineoplastics
  Structure

 Mechanism of Gemcitabine-Cedazuridine Interaction (Severity Level: Moderate)
     Non-CYP450 enzyme inhibition Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Gemcitabine Cedazuridine
      Mechanism Cytidine deaminase substrate Cytidine deaminase inhibitor
      Key Mechanism Factor 1
Factor Name Cytidine deaminase
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Structure Sequence
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ
Gene Name CDA
Uniprot ID CDD_HUMAN
KEGG Pathway hsa:978
Protein Family Cytidine and deoxycytidylate deaminase family
Protein Function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
    Click to Show/Hide
      Mechanism Description
  • Decreased metabolism of Gemcitabine caused by Cedazuridine mediated inhibition of non-CYP450 enzyme

Recommended Action
      Management Coadministration of cedazuridine with drugs that are metabolized by CDA should generally be avoided.

References
1 Bhatla D, Gerbing RB, Alonzo TA, et.al "Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia." Br J Haematol 144 (2009): 388-94. [PMID: 19036079]
2 Product Information. Inqovi (cedazuridine-decitabine). Taiho Oncology, Inc., Princeton, NJ.
3 Product Information. Xeloda (capecitabine). Roche Laboratories, Nutley, NJ.