Details of Drug

Details of Drug

 Drug General Information (ID: D0270)
  Drug Name
Cedazuridine
  Drug Type Small molecule
  Drug Synonymous
Cedazuridine; 1141397-80-9; UNII-39IS23Q1EW; 39IS23Q1EW; CHEMBL3237547; E7727; (4R)-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one; (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine; (R)-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one; Cedazuridine [INN]; Cedazuridine [USAN]; Cedazuridine [USAN:INN]; SCHEMBL172256; GTPL11101; EX-A5549; BDBM50007029; WHO 10741; ASTX727 (cedazuridine + decitabine); ASTX727 COMPONENT CEDAZURIDINE; AT22227; ASTX-727 COMPONENT CEDAZURIDINE; compound 7a [PMID: 24520856]; HY-109081; E-7727; A937507; Uridine, 2'-deoxy-2',2'-difluoro-3,4,5,6-tetrahydro-, (4R)-; (4R)-4-Hydroxy-1-(2,2-difluoro-2-deoxy-beta-D-ribofuranosyl)-3,4,5,6-tetrahydropyrimidine-2(1H)-one
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  Therapeutic Class Antineoplastics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C9H14F2N2O5
  InChI InChI=1S/C9H14F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h4-7,14-16H,1-3H2,(H,12,17)/t4-,5-,6-,7-/m1/s1
  InChIKey VUDZSIYXZUYWSC-DBRKOABJSA-N
  Canonical SMILES C1CN(C(=O)N[C@@H]1O)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F
  External Link
Pubchem ID 25267009

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
BM018  Non-CYP450 enzyme inhibition
  Relation Graph
 Full list of drugs interacting with Cedazuridine
      Affected intra/extra-hepatic metabolism
   Non-CYP450 enzyme inhibition Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0134
 
Azacitidine
 
C8H12N4O5
 
9444 
Moderate    Inter Info   
[1], [2], [3]
D0249
 
Capecitabine
 
C15H22FN3O6
 
60953 
Moderate    Inter Info   
[1], [2], [3]
D0405
 
Cytarabine (liposomal)
 
C9H13N3O5
 
6253 
Moderate    Inter Info   
[1], [2], [3]
D0714
 
Gemcitabine
 
C9H11F2N3O4
 
60750 
Moderate    Inter Info   
[1], [2], [3]
References
1 Bhatla D, Gerbing RB, Alonzo TA, et.al "Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia." Br J Haematol 144 (2009): 388-94. [PMID: 19036079]
2 Product Information. Inqovi (cedazuridine-decitabine). Taiho Oncology, Inc., Princeton, NJ.
3 Product Information. Xeloda (capecitabine). Roche Laboratories, Nutley, NJ.