Drug General Information (ID: DDIFQO9LVX)
Drug Name			Furosemide		Drug Info		Aminolevulinic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Malignancy Photosensitizers
Structure

Mechanism of Furosemide-Aminolevulinic acid Interaction (Severity Level: Major)
Increased risk of photosensitivity reactions Click to Show/Hide Mechanism Graph
Drug Name		Furosemide				Aminolevulinic acid
Mechanism		Photosensitivity reactions				Photosensitivity reactions
Key Mechanism Factor 1
		Factor Name		Photosensitivity reactions
		Factor Description		Drug-induced photosensitivity reactions occur when certain photosensitizing drugs cause unexpected sunburn or dermatitis (dry, bumpy or blistering rash) on sun-exposed skin (face, neck, arms, backs of hands, and often lower legs and feet). The rash may or may not be itchy.
Mechanism Description		Increased risk of photosensitivity reactions by the combination of Furosemide and Aminolevulinic acid

Recommended Action
Management		Photosensitizing agents (e.g., fluoroquinolones, phenothiazines, retinoids, sulfonamides, sulfonylureas, tetracyclines, thiazide diuretics, griseofulvin, St. John's wort) and topical preparations containing aminolevulinic acid should generally not be administered for 24 hours before and after oral administration of aminolevulinic acid.

References
1	Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2	Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.