Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIFDTB6OL)
  Drug Name Diphenhydramine Drug Info Aripiprazole Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiallergic Agents Antipsychotic Agents
  Structure

 Mechanism of Diphenhydramine-Aripiprazole Interaction (Severity Level: Moderate)
     Antagonize the effects of neuroleptic agents Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Diphenhydramine Aripiprazole
      Mechanism Central anticholinergic effect
Muscarinic acetylcholine receptor  Antagonist 		Neuroleptic agents
Dopamine receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Muscarinic acetylcholine receptor M Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
    Click to Show/Hide
      Key Mechanism Factor 2
Factor Name Dopamine receptor Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
    Click to Show/Hide
      Mechanism Description
  • Antagonize the effect of Aripiprazole when combined with Diphenhydramine 

Recommended Action
      Management Caution is advised if anticholinergic agents are used with neuroleptic agents, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Prophylactic administration of anticholinergic agents is sometimes given clinically during neuroleptic therapy for drug-induced parkinsonism or extrapyramidal symptoms but may not always be appropriate.

References
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