Details of Drug

Drug General Information (ID: D0502)
Drug Name	Diphenhydramine
Drug Type	Small molecule
Drug Synonymous	diphenhydramine; 58-73-1; Benadryl; Benzhydramine; Probedryl; Alledryl; Antistominum; Dihidral; 2-(Benzhydryloxy)-N,N-dimethylethanamine; Benzhydraminum; Benzhydroamina; Diphantine; Difenhydramin; Ibiodral; Difedryl; Dibondrin; Mephadryl; Desentol; Dermistina; Betramin; Benzhydril; Benzantine; Benachlor; Bagodryl; Syntedril; Novamina; Medidryl; Hyadrine; Histaxin; Etanautine; Drylistan; Diabylen; Diabenyl; Dermodrin; Benodine; Baramine; Allergical; Debendrin; Benadrin; Dabylen; Antomin; Nausen; Benapon; Dylamon; Benylin; Benylan; Benodin; Amidryl; Aleryl; Allerdryl; Allergeval; Allergina; Allergival; Antitussive; Automin; Banophen; Beldin; Belix; Bena; Benhydramin; Benzhydryl; Compoz; Dibendrin; Dibenil; Difenhidramina; Difenidramina; Dimedrol; Dimedryl; Dimehydrinate; Diphen; Diphenhist; Diphenhydraminum; Diphenylhydramin; Diphenylhydramine; Dryistan; Genahist; Hydramine; Hyrexin; Restamin; Rigidil; Siladryl; Silphen; Syntodril; Allergan B; Allermax Caplets; BENADRYL HCl; Banophen Caplets; Benadryl Allergy; Difenidramina [Italian]; Dimedrol base; Diphen Cough; Diphenhist Captabs; Diphenhydramine Base; Diphenhydramine HCl; Nytol Quickcaps; Nytol Quickgels;Twilite Caplets; Unisom Sleepgels Maximum Strength; Dormarex 2; FAR 90X2; PM 255; S51; Aller-Med; Ben-allergin; Benadryl (TN); Benadryl (hydrochloride); Beta-Dimethylaminoethanol diphenylmethyl ether; Beta-Dimethylaminoethylbenzhydrylether; Beta-dimethylaminoethyl benzhydryl ether; Difenhidramina [INN-Spanish]; Dimedrol (TN); Diphenhydraminum [INN-Latin]; Nervine Nighttime Sleep-Aid; Nytol (TN); O-Benzhydryldimethylaminoethanol; Restamin (TN); Sleep-Eze D; Sleep-Eze D Extra Strength; DIPHENHYDRAMINE, ANTISTOMINUM, BENZHYDRAMINE; Diphenhydramine (JP15/INN); Diphenhydramine [INN:BAN:JAN]; Alpha-(2-Dimethylaminoethoxy)diphenylmethane; N-(Benzhydryloksy-etylo)dwumetyloamina; N-(Benzhydryloksy-etylo)dwumetyloamina [Polish]; Beta-Dimethylamino-aethyl-benzhydryl-aether; Beta-Dimethylamino-aethyl-benzhydryl-aether [German]; N,N-Dimethyl-2-(diphenylmethoxy)-ethylamine hydrochloride; N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE; N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine; 2-(Benzhydryloxy)-N,N-dimethylethylamine; 2-(Benzhydryloxy)-N,N-dimethylethylamine, hydrochloride; 2-(Diphenylmethoxy)-N,N-dimethylethylamine; 2-(diphenylmethoxy)-N,N-dimethylethanamine; 2-Diphenylmethoxy-N,N-dimethylethylamine; 2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine; 2-benzhydryloxy-N,N-dimethylethanamine; 2-benzhydryloxyethyl-N,N-dimethylammonium; 2-diphenylmethoxy-N,N-demthylethanamine; 2PM Click to Show/Hide
Disease Class	AB31: Episodic vestibular syndrome
Therapeutic Class	Antiallergic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H21NO
InChI	1S/C17H21NO/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
InChIKey	ZZVUWRFHKOJYTH-UHFFFAOYSA-N
Canonical SMILES	CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
External Link
	Pubchem ID	3100
	CAS Number	58-73-1
	CHEBI ID	4636
	TTD ID	D01FGR
	INTEDE ID	DR0514
	VARIDT ID	DR00385

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM033 Additive anticholinergic effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM054 Increased risk of GI mucosal injury/bleeding risk BM061 Increased risk of hyperpyrexia BM075 Increased risk of photosensitivity reactions BM076 Increased risk of prolong QT interval BM091 Antagonize the effect of cholinergic agents BM102 Antagonize the effects of neuroleptic agents BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Diphenhydramine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[1], [115], [126]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[1]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[2], [3]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [3], [46], [47], [48], [49], [50], [51], [52], [53]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[80], [81], [82]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[90]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[100]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[109]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[117]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[118]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[58], [121]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[134]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[135]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[136]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[3]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[140]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[147], [148]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[152]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[154], [155], [156]
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[70], [72], [78]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0197		Botulinum Toxin Type B	NA	NA	Moderate		Inter Info	[83], [84], [85]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[101], [102], [103], [104], [105], [106], [107], [108]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[70], [72], [78]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[70], [72], [78]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[70], [72], [78]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[70], [72], [78]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[101], [102], [103], [104], [105], [106], [107], [108]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[101], [102], [103], [104], [105], [106], [107], [108]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[70], [72], [78]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[101], [102], [103], [104], [105], [106], [107], [108]
D0998		Memantine	C12H21N	4054	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79]
D0843		Ipratropium (nasal)	C20H30NO3+	657309	Minor		Inter Info	[161], [162], [122]
	Additive CNS depression effects					Drug Num: 122
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[4], [5]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[18], [19]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[54]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[55]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[56], [57], [58]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[59], [60], [61]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[59], [60], [61]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[59], [60], [61]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[86], [58], [87]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[59], [60], [61]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[59], [60], [61]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[59], [60], [61]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[59], [60], [61]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[59], [60], [61]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[59], [60], [61]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[59], [60], [61]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[88], [89]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[59], [60], [61]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[59], [60], [61]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[59], [60], [61]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[59], [60], [61]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[59], [60], [61]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[59], [60], [61]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[59], [60], [61]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[59], [60], [61]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[59], [60], [61]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[59], [60], [61]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[59], [60], [61]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[114]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[59], [60], [61]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[59], [60], [61]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[59], [60], [61]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[59], [60], [61]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[59], [60], [61]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[59], [60], [61]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[59], [60], [61]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[59], [60], [61]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[59], [60], [61]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[59], [60], [61]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[59], [60], [61]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[59], [60], [61]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[110], [120]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[59], [60], [61]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[59], [60], [61]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[59], [60], [61]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[124], [115], [125]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[127], [110], [58], [128], [129], [130], [131], [132], [133]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[59], [60], [61]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[59], [60], [61]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[59], [60], [61]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[59], [60], [61]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[59], [60], [61]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[59], [60], [61]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[59], [60], [61]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[59], [60], [61]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[59], [60], [61]
D1183		Opium	NA	NA	Moderate		Inter Info	[59], [60], [61]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[59], [60], [61]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[59], [60], [61]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[59], [60], [61]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[59], [60], [61]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[59], [60], [61]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[127], [110], [58], [128], [129], [130], [131], [132], [133]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[59], [60], [61]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[59], [60], [61]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[59], [60], [61]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[59], [60], [61]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[59], [60], [61]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[59], [60], [61]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[59], [60], [61]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[59], [60], [61]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[59], [60], [61]
D1675		Valerian	NA	NA	Moderate		Inter Info	[59], [60], [61]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[59], [60], [61]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[59], [60], [61]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[59], [60], [61]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[59], [60], [61]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[59], [60], [61]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[59], [60], [61]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[149]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[59], [60], [61]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[59], [60], [61]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[59], [60], [61]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[59], [60], [61]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[59], [60], [61]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[59], [60], [61]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[59], [60], [61]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[59], [60], [61]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[59], [60], [61]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[59], [60], [61]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[59], [60], [61]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[59], [60], [61]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[59], [60], [61]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[59], [60], [61]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[59], [60], [61]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[59], [60], [61]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[59], [60], [61]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[59], [60], [61]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[59], [60], [61]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[59], [60], [61]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[59], [60], [61]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[59], [60], [61]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[59], [60], [61]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[127], [110], [58], [128], [129], [130], [131], [132], [133]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[59], [60], [61]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[59], [60], [61]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[59], [60], [61]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[59], [60], [61]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[59], [60], [61]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[59], [60], [61]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[153]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[59], [60], [61]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[157]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[59], [60], [61]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[127], [110], [58], [128], [129], [130], [131], [132], [133]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[59], [60], [61]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[59], [60], [61]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[59], [60], [61]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[59], [60], [61]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[59], [60], [61]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[59], [60], [61]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[59], [60], [61]
	Additive hypotensive effects					Drug Num: 51
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[62], [63], [64]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[62], [63], [64]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[62], [63], [64]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[62], [63], [64]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[62], [63], [64]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[62], [63], [64]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[62], [63], [64]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[62], [63], [64]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[62], [63], [64]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[62], [63], [64]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[62], [63], [64]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[62], [63], [64]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[62], [63], [64]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[62], [63], [64]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[62], [63], [64]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[62], [63], [64]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[62], [63], [64]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[62], [63], [64]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[62], [63], [64]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[62], [63], [64]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[62], [63], [64]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[62], [63], [64]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[62], [63], [64]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[62], [63], [64]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[62], [63], [64]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[62], [63], [64]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[62], [63], [64]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[62], [63], [64]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[62], [63], [64]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[62], [63], [64]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[62], [63], [64]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[62], [63], [64]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[62], [63], [64]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[62], [63], [64]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[62], [63], [64]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[62], [63], [64]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[62], [63], [64]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[62], [63], [64]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[62], [63], [64]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[62], [63], [64]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[62], [63], [64]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[62], [63], [64]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[62], [63], [64]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[62], [63], [64]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[62], [63], [64]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[62], [63], [64]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[62], [63], [64]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[62], [63], [64]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[62], [63], [64]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[62], [63], [64]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[62], [63], [64]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[150], [58], [151]
	Increased risk of prolong QT interval					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0200		Bretylium	C11H17BrN+	2431	Moderate		Inter Info	[110], [111], [112], [113]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[110], [111], [112], [113]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[110], [111], [112], [113]
D0787		Ibutilide	C20H36N2O3S	60753	Moderate		Inter Info	[110], [111], [112], [113]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[110], [111], [112], [113]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[110], [111], [112], [113]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[58], [119]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0440		Demecarium (ophthalmic)	C32H52N4O4+2	5966	Moderate		Inter Info	[98], [99]
D0015		Acetylcholine	C7H16NO2+	187	Moderate		Inter Info	[98], [99]
D1289		Pilocarpine (ophthalmic)	C11H16N2O2	5910	Moderate		Inter Info	[98], [99]
D1362		Prucalopride	C18H26ClN3O3	3052762	Moderate		Inter Info	[138], [139]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[141], [142], [143], [144], [145], [146]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[98], [99]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[141], [142], [143], [144], [145], [146]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Moderate		Inter Info	[98], [99]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[141], [142], [143], [144], [145], [146]
D1286		Physostigmine (ophthalmic)	C15H21N3O2	5983	Moderate		Inter Info	[98], [99]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[141], [142], [143], [144], [145], [146]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[141], [142], [143], [144], [145], [146]
	Antagonize the effects of neuroleptic agents					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[68], [91], [79], [92], [93], [78], [66], [75], [69], [94], [95], [72], [74], [67], [96], [73], [71], [70], [76], [97], [77]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[68], [91], [79], [92], [93], [78], [66], [75], [69], [94], [95], [72], [74], [67], [96], [73], [71], [70], [76], [97], [77]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[68], [91], [79], [92], [93], [78], [66], [75], [69], [94], [95], [72], [74], [67], [96], [73], [71], [70], [76], [97], [77]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[68], [91], [79], [92], [93], [78], [66], [75], [69], [94], [95], [72], [74], [67], [96], [73], [71], [70], [76], [97], [77]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[68], [91], [79], [70], [78], [94], [72], [92], [67], [71], [76], [66], [97], [69], [77], [96], [93], [75], [95], [74], [73]
	Diminish the response to diagnostic skin test antigens					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[98], [115], [116]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[98], [115], [116]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[98], [115], [116]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1807		Histamine	C5H9N3	774	Moderate		Inter Info	[122], [115], [123]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[58], [137], [115]
D1812		Hyaluronidase	C17H24BrNO2	91820602	Minor		Inter Info	[158], [159], [160]

References
1	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
2	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
3	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
4	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
5	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
6	Farquharson-Roberts MA, Giddings AE, Nunn AJ "Perforation of small bowel due to slow release potassium chloride (slow-K)." Br Med J 3 (1975): 206. [PMID: 1148734]
7	Heffernan SJ, Murphy JJ "Ulceration of small intestine and slow-release potassium tablets." Br Med J 2 (1975): 746. [PMID: 1139204]
8	Lambert JR, Newman A "Ulceration and stricture of the esophagus due to oral potassium chloride (slow release tablet) therapy." Am J Gastroenterol 73 (1980): 508-11. [PMID: 7424872]
9	Leijonmarck CE, Raf L "Gastrointestinal lesions and potassium chloride supplements." Lancet 1 (1985): 56-7. [PMID: 2856988]
10	Leijonmarck CE, Raf L "Ulceration of the small intestine due to slow-release potassium chloride tablets." Acta Chir Scand 151 (1985): 273-8. [PMID: 4013604]
11	Lofgren RP, Rothe PR, Carlson GJ "Jejunal perforation associated with slow-release potassium chloride therapy." South Med J 75 (1982): 1154-5. [PMID: 7123349]
12	McMahon FG, Ryan JR, Akdamar K, Ertan A "Effect of potassium chloride supplements on upper gastrointestinal mucosa." Clin Pharmacol Ther 35 (1984): 852-5. [PMID: 6734038]
13	McMahon FG, Ryan JR, Akdamar K, Ertan A "Upper gastrointestinal lesions after potassium chloride supplements: a controlled clinical trial." Lancet 2 (1982): 1059-61. [PMID: 6127542]
14	Product Information. K-Dur (potassium chloride). Schering Laboratories, Kenilworth, NJ.
15	Product Information. Urocit (potassium citrate). Mission Pharmacal Company, San Antonio, TX.
16	Weiss SM, Rutenberg HL, Paskin DL, Zaren HA "Gut lesions due to slow-release KCI tablets." N Engl J Med 296 (1977): 111-2. [PMID: 830293]
17	Wynn V "Potassium chloride and bowel ulceration." Br Med J 5477 (1965): 1546. [PMID: 5850476]
18	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
19	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
20	Amchin J, Ereshefsky L, Zarycranski W, Taylor K, Albano D, Klockowski PM "Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe." J Clin Pharmacol 41 (2001): 443-51. [PMID: 11304901]
21	Aubert RE, Stanek EJ, Yao J, et al "Increased risk of breast cancer recurrence in women initiating tamoxifen with CYP2D6 inhibitors".
22	Bonanni B, Macis D, Maisonneuve P, et al. "Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial." J Clin Oncol 24 (2006): 3708-9. [PMID: 16877740]
23	Borges S, Desta Z, Li L, et al. "Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment." Clin Pharmacol Ther 80 (2006): 61-74. [PMID: 16815318]
24	Borgna JL, Rochefort H "Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues." J Biol Chem 256 (1981): 859-68. [PMID: 7451477]
25	Brauch H, Murdter TE, Eichelbaum M, Schwab M "Pharmacogenomics of tamoxifen therapy." Clin Chem 55 (2009): 1770-82. [PMID: 19574470]
26	Coller JK, Krebsfaenger N, Klein K, et al. "The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver." Br J Clin Pharmacol 54 (2002): 157-167. [PMID: 12207635]
27	Crewe HK, Lennard MS, Tucker GT, Woods FR, Haddock RE "The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes." Br J Clin Pharmacol 34 (1992): 262-5. [PMID: 1389951]
28	Dehal SS, Kupfer D "CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver." Cancer Res 57 (1997): 3402-6. [PMID: 9270005]
29	Desta Z, Flockhart DA "Germline pharmacogenetics of tamoxifen response: have we learned enough?" J Clin Oncol 25 (2007): 5147-9. [PMID: 18024859]
30	Desta Z, Ward BA, Soukhova NV, Flockhart DA "Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6." J Pharmacol Exp Ther (2004):. [PMID: 15159443]
31	Dezentje VO, Guchelaar HJ, Nortier JW, van de Velde CJ, Gelderblom H "Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer." Clin Cancer Res 15 (2009): 15-21. [PMID: 19118028]
32	Gaston C, Kolesar J "Clinical Significance of CYP2D6 Polymorphisms and Tamoxifen in Women with Breast Cancer." Clin Adv Hematol Oncol 6 (2008): 825-33. [PMID: 19194367]
33	Goetz MP, Kamal A, Ames MM "Tamoxifen Pharmacogenomics: The Role of CYP2D6 as a Predictor of Drug Response." Clin Pharmacol Ther (2007):. [PMID: 17882159]
34	Goetz MP, Loprinzi CL "A hot flash on tamoxifen metabolism." J Natl Cancer Inst 95 (2003): 1734-5. [PMID: 14652227]
35	Goetz MP, Rae JM, Suman VJ, et al. "Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes." J Clin Oncol 23 (2005): 9312-8. [PMID: 16361630]
36	Henry NL, Stearns V, Flockhart DA, Hayes DF, Riba M "Drug interactions and pharmacogenomics in the treatment of breast cancer and depression." Am J Psychiatry 165 (2008): 1251-5. [PMID: 18829880]
37	Jin Y, Desta Z, Stearns V, et al. "CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment." J Natl Cancer Inst 97 (2005): 30-9. [PMID: 15632378]
38	Johnson MD, Zuo H, Lee KH, et al. "Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen." Breast Cancer Res Treat 85 (2004): 151-9. [PMID: 15111773]
39	Jordan VC "Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance." Breast Cancer Res Treat 2 (1982): 123-38. [PMID: 6184101]
40	Jordan VC, Collins MM, Rowsby L, Prestwich G "A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity." J Endocrinol 75 (1977): 305-16. [PMID: 591813]
41	Lash TL, Pedersen L, Cronin-Fenton D, et al "Tamoxifen's protection against breast cancer recurrence is not reduced by concurrent use of the SSRI citalopram." Br J Cancer 99 (2008): 616-21. [PMID: 20385012]
42	Lehmann D, Nelsen J, Ramanath V, Newman N, Duggan D, Smith A "Lack of attenuation in the antitumor effect of tamoxifen by chronic CYP isoform inhibition." J Clin Pharmacol 44 (2004): 861-5. [PMID: 15286089]
43	Lim HS, Ju Lee H, Seok Lee K, Sook Lee E, Jang IJ, Ro J "Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer." J Clin Oncol 25 (2007): 3837-45. [PMID: 17761971]
44	McCaffrey P "Genetics and drug interactions affect tamoxifen metabolism." Lancet Oncol 6 (2005): 72. [PMID: 15704296]
45	Ponzone R, Biglia N, Sismondi P "Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine." J Natl Cancer Inst 96 (2004): 883-4 author reply 884-5. [PMID: 15173274]
46	Rochat B "Role of cytochrome p450 activity in the fate of anticancer agents and in drug resistance : focus on tamoxifen, Paclitaxel and imatinib metabolism." Clin Pharmacokinet 44 (2005): 349-66. [PMID: 15828850]
47	Schroth W, Antoniadou L, Fritz P, et al. "Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes." J Clin Oncol 25 (2007): 5187-93. [PMID: 18024866]
48	Stearns V, Johnson MD, Rae JM, et al. "Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine." J Natl Cancer Inst 95 (2003): 1758-64. [PMID: 14652237]
49	Wegman P, Elingarami S, Carstensen J, Stal O, Nordenskjold B, Wingren S "Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer." Breast Cancer Res 9 (2007): R7. [PMID: 17244352]
50	Wegman P, Vainikka L, Stal O, et al "Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients." Breast Cancer Res 7 (2005): R284-90. [PMID: 15987423]
51	Young D "Genetics examined in tamoxifen's effectiveness: recurrence warning urged for labeling." Am J Health Syst Pharm 63 (2006): 2286, 2296. [PMID: 17105997]
52	Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM "Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen." Drug Metab Dispos 30 (2002): 869-74. [PMID: 12124303]
53	Ratliff B, Dietze EC, Bean GR, Moore C, Wanko S, Seewaldt VL "Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine." J Natl Cancer Inst 96 (2004): 883 author reply 884-5. [PMID: 15173275]
54	Product Information. Topamax (topiramate). Ortho Pharmaceutical Corporation, Raritan, NJ.
55	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
56	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
57	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.
58	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
59	Divoll M, Greenblatt DJ, Lacasse Y, Shader RI "Benzodiazepine overdosage: plasma concentrations and clinical outcome." Psychopharmacology (Berl) 73 (1981): 381-3. [PMID: 6789361]
60	Grabowski BS, Cady WJ, Young WW, Emery JF "Effects of acute alcohol administration on propranolol absorption." Int J Clin Pharmacol Ther Toxicol 18 (1980): 317-9. [PMID: 7429677]
61	Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
62	Ellison JM, Milofsky JE, Ely E "Fluoxetine-induced bradycardia and syncope in two patients." J Clin Psychiatry 51 (1990): 385-6. [PMID: 2211552]
63	Feder R "Bradycardia and syncope induced by fluoxetine." J Clin Psychiatry 52 (1991): 139. [PMID: 2005082]
64	Sternbach H "Fluoxetine-associated potentiation of calcium-channel blockers." J Clin Psychopharmacol 11 (1991): 390-1. [PMID: 1770159]
65	Cohen MA, Alfonso CA, Mosquera M. Development of urinary retention during treatment with clozapine and meclizine [published correction appears in Am J Psychiatry 1994 Jun;151(6):952]. Am J Psychiatry. 1994;151(4):619-620. [PMID: 8147469]
66	Forester D "Fatal drug-induced heat stroke." JACEP 7 (1978): 243-4. [PMID: 661049]
67	Gershon S, Neubauer H, Sundland DM "Interaction between some anticholinergic agents and phenothiazines." Clin Pharmacol Ther 6 (1965): 749-56. [PMID: 4378954]
68	Hvizdos AJ, Bennett JA, Wells BG, Rappaport KB, Mendel SA "Anticholinergic psychosis in a patient receiving usual doses of haloperidol." Clin Pharm 2 (1983): 174-8. [PMID: 6883947]
69	Johnson AL, Hollister LE, Berger PA "The anticholinergic intoxication syndrome: diagnosis and treatment." J Clin Psychiatry 42 (1981): 313-7. [PMID: 7251568]
70	Kulik AV, Wilbur R "Delirium and stereotypy from anticholinergic antiparkinson drugs." Prog Neuropsychopharmacol Biol Psychiatry 6 (1982): 75-82. [PMID: 7202232]
71	Lee BS "Possibility of hyperpyrexia with antipsychotic and anticholinergic drugs." J Clin Psychiatry 47 (1986): 571. [PMID: 3771507]
72	Mann SC, Boger WP "Psychotropic drugs, summer heat and humidity, and hyperplexia: a danger restated." Am J Psychiatry 135 (1978): 1097-100. [PMID: 29501]
73	Moreau A, Jones BD, Banno V "Chronic central anticholinergic toxicity in manic depressive illness mimicking dementia." Can J Psychiatry 31 (1986): 339-41. [PMID: 3708528]
74	Product Information. Artane (trihexyphenidyl). Lederle Laboratories, Wayne, NJ.
75	Product Information. Cogentin (benztropine). Merck & Co, Inc, West Point, PA.
76	Sarnquist F, Larson CP Jr "Drug-induced heat stroke." Anesthesiology 39 (1973): 348-50. [PMID: 4728582]
77	Stadnyk AN, Glezos JD "Drug-induced heat stroke." Can Med Assoc J 128 (1983): 957-9. [PMID: 6831343]
78	Warnes H, Lehmann HE, Ban TA "Adynamic ileus during psychoactive medication: a report of three fatal and five severe cases." Can Med Assoc J 96 (1967): 1112-3. [PMID: 6021058]
79	Zelman S, Guillan R "Heat stroke in phenothiazine-treated patients: a report of three fatalities." Am J Psychiatry 126 (1970): 1787-90. [PMID: 5441734]
80	Belle DJ, Ernest CS, Sauer JM, Smith BP, Thomasson HR, Witcher JW "Effect of potent CYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics." J Clin Pharmacol 42 (2002): 1219-27. [PMID: 12412820]
81	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
82	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
83	Product Information. Botox (onabotulinumtoxin A). Allergan Inc, Irvine, CA.
84	Product Information. Myobloc (botulinum toxin type B) Elan Pharmaceuticals, S. San Francisco, CA.
85	Product Information. Xeomin (botulinum toxin type A (obsolete) (botulinum toxin type A)). Merz Pharmaceuticals, Greensboro, NC.
86	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
87	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
88	Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
89	Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
90	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
91	Rockland L, Cooper T, Schwartz F, Weber D, Sullivan T "Effects of trihexyphenidyl on plasma chlorpromazine in young schizophrenics." Can J Psychiatry 35 (1990): 604-7. [PMID: 2268840]
92	Kwok JS, Chan TY "Recurrent heat-related illnesses during antipsychotic treatment." Ann Pharmacother 39 (2005): 1940-2. [PMID: 16174785]
93	Byerly MJ, Christensen RC, Evans DL "Delirium associated with a combination of sertraline, haloperidol, and benztropine." Am J Psychiatry 153 (1996): 965-6. [PMID: 8659626]
94	Roth A, Akyol S, Nelson JC "Delirium associated with the combination of a neuroleptic, an SSRI, and benztropine." J Clin Psychiatry 55 (1994): 492-5. [PMID: 7989283]
95	Hansen LB, Elley J, Christensen TR, Larsen NE, Naestoft J, Hvidberg EF "Plasma levels of perphenazine and its major metabolites during simultaneous treatment with anticholinergic drugs." Br J Clin Pharmacol 7 (1979): 75-80. [PMID: 760745]
96	Rivera-Calimlim L, Nasrallah H, Strauss J, Lasagna L "Clinical response and plasma levels: effect of dose, dosage schedules, and drug interactions on plasma chlorpromazine levels." Am J Psychiatry 133 (1976): 646-52. [PMID: 5901]
97	Singh MM, Kay SR "Therapeutic antagonism between anticholinergic antiparkinsonism agents and neuroleptics in schizophrenia: implications for a neuropharmacological model." Neuropsychobiology 5 (1979): 74-86. [PMID: 34804]
98	Multum Information Services, Inc. Expert Review Panel.
99	Product Information. Pilopine HS (pilocarpine ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
100	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
101	Cole JM, Sheehan AH, Jordan JK "Concomitant use of ipratropium and tiotropium in chronic obstructive plmonary disease." Ann Pharmacother 46 (2012): 1717-21. [PMID: 23170031]
102	Product Information. Anoro Ellipta (umeclidinium-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
103	Product Information. Atrovent (ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
104	Product Information. Combivent (albuterol-ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
105	Product Information. Qbrexza (glycopyrrolate topical). Dermira, Inc., Menlo Park, CA.
106	Product Information. Spiriva (tiotropium). Boehringer Ingelheim, Ridgefield, CT.
107	Product Information. Tudorza Pressair (aclidinium). Forest Pharmaceuticals, St. Louis, MO.
108	Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
109	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
110	Cerner Multum, Inc. "Australian Product Information.".
111	Husain Z, Hussain K, Nair R, Steinman R "Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug." Cardiology 17 (2010): 509-11. [PMID: 20865683]
112	Poluzzi E, Raschi E, Godman B, et.al "Pro-arrhythmic potential of oral antihistamines (H1): Combining adverse event reports with drug utilization data across Europe." PLoS One 10 (2014): epub. [PMID: 25785934]
113	Shah A, Yousuf T, Ziffra J, Zaidi A, Raghuvir R "Diphenhydramine and QT prolongation - A rare cardiac side effect of a drug used in common practice." J Cardiol Cases 12 (2015): 126-9. [PMID: 30546575]
114	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
115	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
116	NLM. National Library of Medicine. NIH. National Institutes of Health "Trichophyton for intradermal skin testing (trichophyton mentagrophytes and trichophyton rubrum) injection.".
117	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
118	Product Information. Vizimpro (dacomitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
119	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
120	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
121	Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
122	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
123	Product Information. Histatrol (histamine phosphate). Center Laboratories, Port Washington, NY.
124	Product Information. Ifex (ifosfamide). Bristol-Myers Squibb, Princeton, NJ.
125	Simonian NA, Gilliam FG, Chiappa KH "Ifosfamide causes a diazepam-sensitive encephalopathy." Neurology 43 (1993): 2700-2
126	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
127	Canadian Pharmacists Association.
128	Ferry T, Ponceau B, Simon M, et al. "Possibly linezolid-induced peripheral and central neurotoxicity: report of four cases." Infection 33 (2005): 151-4. [PMID: 15940417]
129	Kahn DA "Possible toxic interaction between cyproheptadine and phenelzine." Am J Psychiatry 144 (1987): 1242-3. [PMID: 3631331]
130	Product Information. Benadryl (diphenhydramine). Parke-Davis, Morris Plains, NJ.
131	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
132	Product Information. Periactin (cyproheptadine). Merck & Co, Inc, West Point, PA.
133	Serio RN "Acute delirium associated with combined diphenhydramine and linezolid use." Ann Pharmacother 38 (2004): 62-5. [PMID: 14742796]
134	Product Information. Belviq (lorcaserin). Eisai Inc, Teaneck, NJ.
135	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
136	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
137	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
138	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
139	Product Information. Resotran (prucalopride). Janssen Pharmaceuticals, Titusville, NJ.
140	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
141	Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC "Explicit criteria for determining inappropriate medication use in nursing home residents." Arch Intern Med 151 (1991): 1825-32. [PMID: 1888249]
142	Carnahan RM, Lund BC, Perry PJ, Chrischilles EA "The concurrent use of anticholinergics and cholinesterase inhibitors: rare event or common practice?" J Am Geriatr Soc 52 (2004): 2082-7. [PMID: 15571547]
143	Edwards KR, O'Connor JT "Risk of delirium with concomitant use of tolterodine and acetylcholinesterase inhibitors." J Am Geriatr Soc 50 (2002): 1165-6. [PMID: 12110086]
144	Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH "Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts." Arch Intern Med 163 (2003): 2716-2724. [PMID: 14662625]
145	Katz IR, Sands LP, Bilker W, DiFilippo S, Boyce A, D'Angelo K "Identification of medications that cause cognitive impairment in older people: the case of oxybutynin chloride." J Am Geriatr Soc 46 (1998): 8-13. [PMID: 9434659]
146	Roe CM, Anderson MJ, Spivack B "Use of anticholinergic medications by older adults with dementia." J Am Geriatr Soc 50 (2002): 836-42. [PMID: 12028169]
147	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
148	Skinner MH, Kuan HY, Pan A, et al. "Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers." Clin Pharmacol Ther 73 (2003): 170-7. [PMID: 12621382]
149	Linnoila M "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol 6 (1973): 107-12. [PMID: 4588850]
150	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
151	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
152	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
153	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
154	Edeki TI, He HB, Wood AJJ "Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops: potential for oral-ophthalmic drug interaction." JAMA 274 (1995): 1611-3. [PMID: 7474246]
155	Fraunfelder FT, Fraunfelder FW Randall JA "Drug-Induced Ocular Side Effects 5th" Boston, MA: Butterworth-Heinemann (2001):.
156	Lewis RV, Lennard MS, Jackson PR, Tucker GT, Ramsay LE, Woods HF "Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics." Br J Clin Pharmacol 19 (1985): 329-33. [PMID: 2859048]
157	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
158	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
159	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
160	Product Information. Vitrase (hyaluronidase). Bausch and Lomb, Rochester, NY.
161	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
162	Product Information. Atrovent nasal spray (ipratropium nasal). Boehringer-Ingelheim, Ridgefield, CT.

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