Drug General Information (ID: DDIFD7OTLP)
Drug Name			Ethanol		Drug Info		Fomepizole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antidotes
Structure

Mechanism of Ethanol-Fomepizole Interaction (Severity Level: Major)
Non-CYP450 enzyme inhibition Click to Show/Hide Mechanism Graph
Drug Name		Ethanol				Fomepizole
Mechanism		Alcohol dehydrogenase substrate				Alcohol dehydrogenase inhibitor
Key Mechanism Factor 1
		Factor Name		Alcohol dehydrogenase				Structure Sequence
		Protein Family		Zinc-containing alcohol dehydrogenase family
		Protein Function		Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060).     Click to Show/Hide
Mechanism Description		Decreased metabolism of Ethanol caused by Fomepizole mediated inhibition of non-CYP450 enzyme

Recommended Action
Management		In general, ethanol and fomepizole should not be coadministered in the treatment of ethylene glycol poisoning.

References
1	Product Information. Antizol (fomepizole). Jazz Pharmaceuticals, Palo Alto, CA.