Drug General Information (ID: DDIFCWY4BV)
  Drug Name Sucralfate Drug Info Diflunisal Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Gi Agents Analgesics
  Structure

 Mechanism of Sucralfate-Diflunisal Interaction (Severity Level: Minor)
     Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Sucralfate Diflunisal
      Mechanism Decrease the bioavailability of diflunisal Diflunisal
      Key Mechanism Factor 1
Factor Name Pharmacokinetic
Factor Description Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Altered absorption of Diflunisal caused by Sucralfate 

References
1 D'Arcy PF, McElnay JC "Drug-antacid interactions: assessment of clinical importance." Drug Intell Clin Pharm 21 (1987): 607-17. [PMID: 2886325]
2 Product Information. Dolobid (diflunisal). Merck & Co, Inc, West Point, PA.
3 Verbeeck R, Tjandramaga TB, Mullie A, Verbesselt R, de Schepper PJ "Effect of aluminum hydroxide on diflunisal absorption." Br J Clin Pharmacol 7 (1979): 519-22. [PMID: 314299]