Drug General Information (ID: DDIF7DJ692)
Drug Name			Oxymetazoline (ophthalmic)		Drug Info		Guanethidine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Decongestants				Antihypertensive Agents
Structure

Mechanism of Oxymetazoline (ophthalmic)-Guanethidine Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Oxymetazoline (ophthalmic)				Guanethidine
Mechanism		Sympathomimetic amine				Potentiate the pharmacologic effects of sympathomimetic amine
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Oxymetazoline (ophthalmic) and Guanethidine

Recommended Action
Management		Due to their pressor effect, sympathomimetic amines should be used cautiously in patients with hypertension. Conversely, alternatives to postganglionic adrenergic blocking agents should be considered in patients treated with sympathomimetic amines. If the combination is used, blood pressure and heart rate should be closely monitored.

References
1	Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
2	Muelheims GH, Entrup RW, Paiewonsky D, Mierzwiak DS "Increased sensitivity of the heart to catecholamine-induced arrhythmias following guanethidine." Clin Pharmacol Ther 6 (1965): 757-62
3	Spiers AS, Calne DB "Action of dopamine on the human iris." Br Med J 4 (1969): 333-5