Details of Drug

Drug General Information (ID: D1205)
Drug Name	Oxymetazoline (ophthalmic)
Drug Type	Small molecule
Drug Synonymous	Hazol; Iliadin; Nafrine; Navasin; Navisin; Nezeril; Oximetazolina; Oximetazolinum; Oxylazine; Oxymetazolinum; Oxymethazoline; Oxymetozoline; Rhinofrenol; Rhinolitan; Sinerol; Dristan Long Lasting Mentholated Nasal Spray; Dristan Long Lasting Nasal Mist; Drixoral Nasal Solution; Oxymeta zoline; Oxymetazoline hydrochloride crystalline; Afrin Cherry 12 Hour Nasal Spray; Afrin Extra Moisturizing 12 Hour Nasal Spray; Afrin Original 12 Hour Nasal Spray; Afrin Original 12 Hour Nose Drops; Afrin Original 12 Hour Pump Mist; Afrin Sinus 12 Hour Nasal Spray; Duramist Plus Up To 12 Hour Nasal Decongestant Spray; Genasal Nasal Spray Up to 12 Hour Relief; H 990; Nasal Relief 12 Hour Nasal Spray; Nostrilla 12 Hour Nasal Decongestant; Vicks Sinex 12 Hour Nasal Spray; Vicks Sinex 12 Hour Ultra Fine Mist for Sinus Relief; Decongestant (TN); Neo-Synephrine 12 Hour Spray; Operil (TN); Oximetazolina [INN-Spanish]; Oxymetazoline (INN); Oxymetazoline [INN:BAN]; Oxymetazolinum [INN-Latin]; Visine L.R; Visine L.R.; Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-(7CI,8CI); Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-(9CI); 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline; 3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-6-tert-butyl-phenol; 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol; 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol; 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol; 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol Click to Show/Hide
Disease Class	9A02: Eyelid inflammatory disorder; MD11: Breathing abnormality
Therapeutic Class	Decongestants
Structure
Structure	3D Structure		2D Structure
Formula	C16H24N2O
InChI	1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
InChIKey	WYWIFABBXFUGLM-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C(=C1CC2=NCCN2)C)O)C(C)(C)C
External Link
	Pubchem ID	4636
	CAS Number	1491-59-4
	CHEBI ID	7862
	TTD ID	D09EBS
	INTEDE ID	DR1224

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM014 Interference of cell/tissue uptake BM018 Non-CYP450 enzyme inhibition BM041 Additive hypertensive effects BM078 Increased risk of rapid heart rate BM083 Potentiated the pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Oxymetazoline (ophthalmic)
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[5]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[15], [16], [17]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[15], [16], [17]
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[15], [16], [17]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[15], [16], [17]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[15], [16], [17]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[15], [16], [17]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[15], [16], [21]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[15], [16], [17]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[15], [16], [17]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[15], [16], [17]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[1], [2], [3]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[1], [3], [4]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[1], [3], [4]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[1], [3], [4]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[1], [3], [4]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[6], [7], [8]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[12], [13], [14]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[18], [4]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[12], [13], [14]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[12], [13], [14]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[6], [7], [8]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[12], [13], [14]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[12], [13], [14]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[12], [13], [14]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[19], [18], [20]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[6], [7], [8]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[12], [13], [14]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[6], [7], [8]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[12], [13], [14]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[12], [13], [14]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[12], [13], [14]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[12], [13], [14]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[12], [13], [14]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[22], [23], [24]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[25]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[6], [7], [8]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[12], [13], [14]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[12], [13], [14]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[12], [13], [14]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[6], [7], [8]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[9], [10], [11]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[9], [10], [11]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[9], [10], [11]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[9], [10], [11]

References
1	Barthel W, Glusa E, Koth W "Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ." Int J Clin Pharmacol Ther Toxicol 25 (1987): 63-9. [PMID: 2881898]
2	Buchanan N, Cane RD, Miller M "Symmetrical gangrene of the extremities associated with the use of dopamine subsequent to ergometrine administration." Intensive Care Med 3 (1977): 55-6. [PMID: 561121]
3	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
4	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
5	Product Information. Azedra (iobenguane I-131). Progenics Pharmaceuticals, Inc., New York, NY.
6	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
7	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
8	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
9	Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
10	Muelheims GH, Entrup RW, Paiewonsky D, Mierzwiak DS "Increased sensitivity of the heart to catecholamine-induced arrhythmias following guanethidine." Clin Pharmacol Ther 6 (1965): 757-62
11	Spiers AS, Calne DB "Action of dopamine on the human iris." Br Med J 4 (1969): 333-5
12	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
13	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
14	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
15	Cusson JR, Goldenberg E, Larochelle P "Effect of a novel monoamine-oxidase inhibitor, moclobemide on the sensitivity to intravenous tyramine and norepinephrine in humans." J Clin Pharmacol 31 (1991): 462-7. [PMID: 2050833]
16	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
17	Thompson DS, Sweet RA, Marzula K, Peredes JC "Lack of interaction of monoamine oxidase inhibitors and epinephrine in an older patient." J Clin Psychopharmacol 17 (1997): 322-3. [PMID: 9241014]
18	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
19	Cerner Multum, Inc. "Australian Product Information.".
20	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
21	Product Information. Xadago (safinamide). US WorldMeds LLC, Louisville , KY.
22	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
23	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
24	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
25	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.

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