Drug General Information (ID: DDIEUM5RPG)
Drug Name			Diethylpropion		Drug Info		Iobenguane (I-123)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Diagnostic Radiopharmaceuticals
Structure

Mechanism of Diethylpropion-Iobenguane (I-123) Interaction (Severity Level: Moderate)
Interference of cell/tissue uptake Click to Show/Hide Mechanism Graph
Drug Name		Diethylpropion				Iobenguane (I-123)
Mechanism		Reduction of Iobenguane I-123 uptake in neuroendocrine tumors				Iobenguane (I-123)
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the distribution of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Interference of cell/tissue uptake of Iobenguane (I-123) by Diethylpropion

Recommended Action
Management		When medically feasible, any drug that blocks norepinephrine uptake or deplete norepinephrine stores should be discontinued for at least five biological half-lives before iobenguane I-123 administration.

References
1	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
2	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
3	Product Information. AdreView (iobenguane I-123). GE Healthcare, Princeton, NJ.