Drug General Information (ID: DDIE0RUTZP)
Drug Name			Orlistat		Drug Info		Thyroid, porcine		Drug Info
Drug Type		Small molecule				Hormones
Therapeutic Class		Antiobesity Agents				Thyroid Drugs

Mechanism of Orlistat-Thyroid, porcine Interaction (Severity Level: Moderate)
Altered Fat-soluble drugs absorption Click to Show/Hide Mechanism Graph
Drug Name		Orlistat				Thyroid, porcine
Mechanism		Decrease fat-soluble agent absorption				Fat-soluble agent
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased absorption of Thyroid, porcine caused by Orlistat

Recommended Action
Management		Orlistat and oral thyroid hormone preparations should be administered at least 4 hours apart. Close clinical and laboratory monitoring of thyroid function is recommended. Patients should be advised to contact their physician if they experience symptoms of hypothyroidism such as fatigue, muscle weakness or pain, joint stiffness, depression, constipation, hoarseness, weight gain, hair loss, brittle nails, pale or dry skin, cold intolerance, memory problems, confusion, or menstrual irregularities.

References
1	Madhava K, Hartley A "Hypothyroidism in thyroid carcinama follow-up: orlistat may inhibit the absorption of thyroxine." Clin Oncol 17 (2005): 492. [PMID: 16149295]
2	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
3	Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.