Drug General Information (ID: DDIE0FOH1R)
Drug Name			Diflunisal		Drug Info		Mestranol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Estrogens
Structure

Mechanism of Diflunisal-Mestranol Interaction (Severity Level: Minor)
Increased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Diflunisal				Mestranol
Mechanism		Diflunisal				Enhance the clearance of diflunisal
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Increased renal excretion of Diflunisal caused by Mestranol

References
1	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
2	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
3	Macdonald JI, Herman RJ, Verbeeck RK "Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal." Eur J Clin Pharmacol 38 (1990): 175-9. [PMID: 2338115]