Drug General Information (ID: DDIE0B7CTW)
Drug Name			Pramipexole		Drug Info		Memantine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiparkinson Agents				Cholinesterase Inhibitors
Structure

Mechanism of Pramipexole-Memantine Interaction (Severity Level: Minor)
Additive dopaminergic effects Click to Show/Hide Mechanism Graph
Drug Name		Pramipexole				Memantine
Mechanism		Dopaminergic effects Dopamine receptor  Agonist				Dopaminergic effects Dopamine receptor  Agonist
Key Mechanism Factor 1
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Additive dopaminergic effects by the combination of Pramipexole and Memantine

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.