Drug General Information (ID: DDIDXQUGJP)
Drug Name			Timolol (ophthalmic)		Drug Info		Tasimelteon		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Timolol (ophthalmic)-Tasimelteon Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Timolol (ophthalmic)				Tasimelteon
Mechanism		Reduce therapeutic efficacy of tasimelteon				Tasimelteon
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Timolol (ophthalmic) when combined with Tasimelteon

Recommended Action
Management		Product labeling for tasimelteon suggests avoiding the nighttime administration of beta-blockers.

References
1	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.