Details of Drug

Drug General Information (ID: D1586)
Drug Name	Timolol (ophthalmic)
Drug Type	Small molecule
Drug Synonymous	Aquanil; Betim; Betimol; Blocadren; Istalol; Optimol; Proflax; TIM; Temserin; Tenopt; Timacar; Timololum; Timopic; Timoptol; Timolol GFS; Timolol [USAN]; Timoptic OcuDose; Apo-Timol; Apo-Timop; Betimol (TN); Blocadren (TN); Istalol (TN); MK-950; Novo-Timol; Nu-Timolol; Phoxal-timolol; Tim-AK; Timolol (INN); Timolol (TN); Timololum [INN-Latin]; Timoptic (TN); Timoptic-XE; Apo-Timol (TN); Apo-Timop (TN); Gen-Timolol (TN); L-714,465; Nu-Timolol (TN); PMS-Timolol (TN); Phoxal-timolol (TN); Tim-AK (TN); Timoptic OcuDose. (TN); Timoptic-XE (TN); S(-)-Timolol maleate; Timolol Maleate, (1:1) Salt; S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole; (-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole; (2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; (2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; (S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol; (S)-timolol Click to Show/Hide
Disease Class	BA00: Essential hypertension
Therapeutic Class	Antiarrhythmic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C13H24N4O3S
InChI	1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1
InChIKey	BLJRIMJGRPQVNF-JTQLQIEISA-N
Canonical SMILES	CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O
External Link
	Pubchem ID	33624
	CAS Number	26839-75-8
	CHEBI ID	9599
	TTD ID	D05UVD
	VARIDT ID	DR00900

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM024 Competitive inhibition of metabolic enzyme BM036 Additive cardiorespiratory depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM048 Increased risk of angioedema/anaphylactoid reactions BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM052 Increased risk of cardiac depression BM057 Increased risk of hyperglycemia BM062 Increased risk of hypertriglyceridemia BM064 Increased risk of hypoglycemia BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM090 Antagonize the effect of bronchodilators BM101 Antagonize the effects of beta receptor blockers BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Timolol (ophthalmic)
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[19]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 55
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[34], [35], [36]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[34], [35], [36]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[34], [35], [36]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[34], [35], [36]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[34], [35], [36]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[34], [35], [36]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[34], [35], [36]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[34], [35], [36]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[34], [35], [36]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[34], [35], [36]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[34], [35], [36]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[34], [35], [36]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[34], [35], [36]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[34], [35], [36]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[34], [35], [36]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[34], [35], [36]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[34], [35], [36]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[34], [35], [36]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[34], [35], [36]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[34], [35], [36]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[34], [35], [36]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[34], [35], [36]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[34], [35], [36]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[34], [35], [36]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[34], [35], [36]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[34], [35], [36]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[34], [35], [36]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[34], [35], [36]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[34], [35], [36]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[34], [35], [36]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[34], [35], [36]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[34], [35], [36]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[34], [35], [36]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[34], [35], [36]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[34], [35], [36]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[34], [35], [36]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[34], [35], [36]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[34], [35], [36]
D1194		Oxamniquine	C14H21N3O3	4612	Moderate		Inter Info	[34], [35], [36]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[34], [35], [36]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[34], [35], [36]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[34], [35], [36]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[34], [35], [36]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[34], [35], [36]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[34], [35], [36]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[34], [35], [36]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[34], [35], [36]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[34], [35], [36]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[99], [100], [101]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[34], [35], [36]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[34], [35], [36]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[34], [35], [36]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[34], [35], [36]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[34], [35], [36]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[55], [56], [57]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[55], [56], [57]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[55], [56], [57]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[55], [56], [57]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[55], [56], [57]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[55], [56], [57]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[55], [56], [57]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[55], [56], [57]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[55], [56], [57]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[55], [56], [57]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[55], [56], [57]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[55], [56], [57]
	Additive hypertensive effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[37], [38], [39]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[37], [38], [39]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[37], [38], [39]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[37], [38], [39]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[37], [38], [39]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[37], [38], [39]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[96], [97]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[96], [97]
	Additive hypotensive effects					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[23], [24], [25]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[26], [27]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[26], [27]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[40], [41], [42]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[26], [27]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[44], [45], [46]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[26], [27]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[44], [45], [46]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[26], [27]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[63], [64], [65]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[26], [27]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[63], [64], [65]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[63], [64], [65]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[26], [27]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[26], [27]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[23], [24], [25]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[77]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[44], [45], [46]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[86], [14], [87]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[44], [45], [46]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[26], [27]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[44], [45], [46]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[26], [27]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[26], [27]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[26], [27]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[44], [45], [46]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[23], [24], [25]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[26], [27]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[23], [24], [25]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[44], [45], [46]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[26], [27]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[44], [45], [46]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[44], [45], [46]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[44], [45], [46]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[23], [24], [25]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[26], [27]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[102], [103], [104]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[23], [24], [25]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1793		Gadodiamide	C16H26GdN5O8	153921	Moderate		Inter Info	[10], [11], [43]
D1783		Ethiodized oil	NA	NA	Moderate		Inter Info	[74], [75], [76]
D1787		Fluorescein	C20H12O5	16850	Moderate		Inter Info	[83], [84], [85]
D1791		Gadobenic acid	C22H28GdN3O11	9852779	Moderate		Inter Info	[10], [11], [43]
D1792		Gadobutrol	C18H31GdN4O9	6102852	Moderate		Inter Info	[10], [11], [43]
D1794		Gadofosveset trisodium	C33H38GdN3Na3O14P	73049652	Moderate		Inter Info	[10], [11], [43]
D1795		Gadopentetic acid	C14H20GdN3O10	6857474	Moderate		Inter Info	[10], [11], [43]
D1796		Gadoteric acid	C16H25GdN4O8	158536	Moderate		Inter Info	[10], [11], [43]
D1797		Gadoteridol	C17H29GdN4O7	60714	Moderate		Inter Info	[10], [11], [43]
D1798		Gadoversetamide	C20H34GdN5O10	444013	Moderate		Inter Info	[10], [11], [43]
D1826		Iopanoic acid	C11H12I3NO2	3735	Moderate		Inter Info	[74], [75], [76]
D1915		Tyropanoic acid	C15H18I3NO3	5611	Moderate		Inter Info	[74], [75], [76]
	Increased risk of atrioventricular block					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1288		Pilocarpine	C11H16N2O2	5910	Moderate		Inter Info	[98]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[11], [113]
	Increased risk of bradycardia					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[10], [11], [12]
D0363		Clonidine	C9H9Cl2N3	2803	Major		Inter Info	[13], [14], [15]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [22]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[28], [29], [30]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[50]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[53], [54]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[58], [59]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[60], [61], [62]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[67]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[11], [68], [69]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[70], [71], [72]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[70], [71], [72]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[73]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[78], [79]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[10], [91]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[53], [54]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[92]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[93]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[94], [10], [95]
D1598		Tocainide	C11H16N2O	38945	Moderate		Inter Info	[107], [108], [109]
	Increased risk of cardiac depression					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1], [2], [3]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1], [2], [3]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[47], [48], [49]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[47], [48], [49]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[47], [48], [49]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[47], [48], [49]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[47], [48], [49]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[80], [81], [82]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[47], [48], [49]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[47], [48], [49]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[47], [48], [49]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[47], [48], [49]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[47], [48], [49]
	Increased risk of hyperglycemia					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[31], [32], [33]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[31], [32], [33]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[31], [32], [33]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[31], [32], [33]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[31], [32], [33]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[31], [32], [33]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[31], [32], [33]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[31], [32], [33]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[31], [32], [33]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[31], [32], [33]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[31], [32], [33]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[31], [32], [33]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[31], [32], [33]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[31], [32], [33]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[31], [32], [33]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[31], [32], [33]
	Increased risk of ventricular arrhythmias					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[10], [11], [106]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0581		Epinephrine	C9H13NO3	5816	Major		Inter Info	[16], [17], [18]
D1016		Methacholine	C8H18NO2+	1993	Major		Inter Info	[20]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1801		Glucagon	C153H225N43O49S	16132283	Minor		Inter Info	[110], [111], [112]
	Antagonize the effect of antihypertensive agents					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[51], [18], [52]
D0101		Arbutamine	C18H23NO4	60789	Moderate		Inter Info	[66]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[51], [18], [52]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[51], [18], [52]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[51], [18], [52]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[51], [18], [52]
	Antagonize the effect of bronchodilators					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0854		Isoetharine	C13H21NO3	3762	Major		Inter Info	[4], [5], [6]
D1570		Theophylline	C7H8N4O2	2153	Major		Inter Info	[7], [8], [9]
D0064		Aminophylline	C16H24N10O4	9433	Major		Inter Info	[7], [8], [9]
D0103		Arformoterol	C19H24N2O4	3083544	Major		Inter Info	[4], [5], [6]
D0544		Dyphylline	C10H14N4O4	3182	Major		Inter Info	[7], [8], [9]
D0691		Formoterol	C19H24N2O4	3410	Major		Inter Info	[4], [5], [6]
D0797		Indacaterol	C24H28N2O3	6918554	Major		Inter Info	[4], [5], [6]
D0924		Levosalbutamol	C13H21NO3	123600	Major		Inter Info	[4], [5], [6]
D1171		Olodaterol	C21H26N2O5	11504295	Major		Inter Info	[4], [5], [6]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[4], [5], [6]
D1201		Oxtriphylline	C12H21N5O3	656652	Major		Inter Info	[7], [8], [9]
D1298		Pirbuterol	C12H20N2O3	4845	Major		Inter Info	[4], [5], [6]
D1374		Racepinephrine	C9H13NO3	838	Major		Inter Info	[4], [5], [6]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[21]
D1438		Salbutamol	C13H21NO3	2083	Major		Inter Info	[4], [5], [6]
D1440		Salmeterol	C25H37NO4	5152	Major		Inter Info	[4], [5], [6]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[4], [5], [6]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Major		Inter Info	[4], [5], [6]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[88], [89], [90]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[105]

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