Drug General Information (ID: DDIDQAN6FP)
Drug Name			Loxapine		Drug Info		Oxymorphone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antipsychotic Agents				Narcotic Analgesics
Structure

Mechanism of Loxapine-Oxymorphone Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Loxapine				Oxymorphone
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Loxapine and Oxymorphone

Recommended Action
Management		The use of opioids in conjunction with benzodiazepines or other CNS depressants should generally be avoided unless alternative treatment options are inadequate. If coadministration is necessary, the dosage and duration of each drug should be limited to the minimum required to achieve desired clinical effect, with cautious titration and dosage adjustments when needed. Patients should be monitored closely for signs and symptoms of respiratory depression and sedation, and advised to avoid driving or operating hazardous machinery.

References
1	Cerner Multum, Inc. "Canadian Product Information.".
2	Product Information. Versacloz (cloZAPine). Jazz Pharmaceuticals, Palo Alto, CA.
3	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
4	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
5	Cerner Multum, Inc. "Australian Product Information.".
6	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
7	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8	US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
9	Product Information. FazaClo (cloZAPine). Jazz Pharmaceuticals, Palo Alto, CA.