Details of Drug

Drug General Information (ID: D0957)
Drug Name	Loxapine
Drug Type	Small molecule
Drug Synonymous	Cloxazepine; Dibenzacepin; Dibenzoazepine; Lossapina; Loxapin; Loxapina; Loxapinsuccinate; Loxapinum; Loxepine; Oxilapine; Lossapina [DCIT]; Loxitane IM; CL 62362; HF 3170; HF3170; Hydrofluoride 3170; LW 3170; S 805; SUM 3170; CL-62362; Loxapac (TN); Loxapina [INN-Spanish]; Loxapinum [INN-Latin]; Loxitane (TN); S-805;SUM-3170; CL-71,563; Loxapine (USAN/INN); Loxapine [USAN:BAN:INN]; Loxapine [USAN:INN:BAN]; 2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine; 2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)oxazepine; 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine; 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine; 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,5]benzoxazepine Click to Show/Hide
Disease Class	6A20: Schizophrenia
Therapeutic Class	Antipsychotic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C18H18ClN3O
InChI	1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
InChIKey	XJGVXQDUIWGIRW-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
External Link
	Pubchem ID	3964
	CAS Number	28400
	CHEBI ID	50841
	TTD ID	D0U5OE

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM033 Additive anticholinergic effects BM034 Additive antidopaminergic effects BM035 Additive antimotility effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM046 Additive serotonergic effects BM054 Increased risk of GI mucosal injury/bleeding risk BM060 Increased risk of hyperprolactinemia BM061 Increased risk of hyperpyrexia BM069 Increased risk of lowers seizure threshold BM076 Increased risk of prolong QT interval BM091 Antagonize the effect of cholinergic agents BM093 Antagonize the effect of dopaminergic agents BM102 Antagonize the effects of neuroleptic agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Loxapine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[142], [143], [155]
D1825		Ioflupane I-123	C18H23FINO2	3086674	Moderate		Inter Info	[142], [143], [156]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[131]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[164]
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 85
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0196		Botulinum toxin type A	NA	NA	Moderate		Inter Info	[92], [93], [94]
D0197		Botulinum Toxin Type B	NA	NA	Moderate		Inter Info	[92], [93], [94]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114]
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[78], [80], [86]
D0051		Amantadine	C10H17N	2130	Moderate		Inter Info	[117], [118]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[78], [80], [86]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[78], [80], [86]
D0734		Glycopyrronium (topical)	C19H28NO3+	3494	Moderate		Inter Info	[108], [110], [111]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0998		Memantine	C12H21N	4054	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[78], [80], [86]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[78], [80], [86]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1590		Tiotropium	C19H22NO4S2+	5487427	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113], [114]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87]
D0843		Ipratropium (nasal)	C20H30NO3+	657309	Minor		Inter Info	[142], [171], [143]
	Additive antidopaminergic effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[26]
D1046		Metoclopramide	C14H22ClN3O2	4168	Major		Inter Info	[35], [5], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[54], [55], [56], [57], [58], [59], [60], [61], [62]
	Additive antimotility effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[163]
	Additive CNS depression effects					Drug Num: 131
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[6], [7], [8], [4], [9], [1], [2], [3], [5]
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[10]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [8], [19], [20], [21], [22], [23], [24], [25]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[27], [28], [29]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[10]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[10]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[52], [53]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[63]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[6], [7], [8], [4], [9], [1], [2], [3], [5]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[10]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[64]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[88], [89], [90]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[88], [89], [90]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[88], [89], [90]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[88], [89], [90]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[105], [106]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[88], [89], [90]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[88], [89], [90]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[88], [89], [90]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[88], [89], [90]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[122], [7], [123]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[88], [89], [90]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[130]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[122], [7], [123]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[122], [7], [123]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[88], [89], [90]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[88], [89], [90]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[88], [89], [90]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[88], [89], [90]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[88], [89], [90]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[88], [89], [90]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[88], [89], [90]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[88], [89], [90]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[88], [89], [90]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[88], [89], [90]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[88], [89], [90]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[88], [89], [90]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[88], [89], [90]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[88], [89], [90]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[88], [89], [90]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[88], [89], [90]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[88], [89], [90]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[88], [89], [90]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[5], [140]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[88], [89], [90]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[141], [142], [70], [7], [143]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[88], [89], [90]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[88], [89], [90]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[88], [89], [90]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[88], [89], [90]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[144]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[88], [89], [90]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[88], [89], [90]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[153], [141], [154]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[88], [89], [90]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[88], [89], [90]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[88], [89], [90]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[88], [89], [90]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[157]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[88], [89], [90]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[88], [89], [90]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[105], [106]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[141], [161], [162]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[88], [89], [90]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[88], [89], [90]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[88], [89], [90]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[88], [89], [90]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[88], [89], [90]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[88], [89], [90]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[141], [166], [143]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D1183		Opium	NA	NA	Moderate		Inter Info	[88], [89], [90]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[88], [89], [90]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[88], [89], [90]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[88], [89], [90]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[88], [89], [90]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[88], [89], [90]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[88], [89], [90]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[88], [89], [90]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[88], [89], [90]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[88], [89], [90]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[88], [89], [90]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[88], [89], [90]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[88], [89], [90]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[88], [89], [90]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[88], [89], [90]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[88], [89], [90]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[88], [89], [90]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[88], [89], [90]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[88], [89], [90]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[88], [89], [90]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[88], [89], [90]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[169]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[88], [89], [90]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[170]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[88], [89], [90]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[88], [89], [90]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[88], [89], [90]
D1675		Valerian	NA	NA	Moderate		Inter Info	[88], [89], [90]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[88], [89], [90]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[88], [89], [90]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[88], [89], [90]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[88], [89], [90]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[88], [89], [90]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[88], [89], [90]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[88], [89], [90]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[88], [89], [90]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[88], [89], [90]
	Additive hypotensive effects					Drug Num: 85
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[6], [70], [3]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[6], [70], [3]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[6], [70], [3]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[65], [66], [67], [68], [6], [69], [70], [71], [3], [4], [72]
	Additive serotonergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[143], [165], [141]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[49], [50], [51]
	Increased risk of lowers seizure threshold					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[30], [31], [32], [33], [34]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[30], [31], [32], [33], [34]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[119], [120]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[145], [146], [147], [148], [149], [150], [151], [152]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[158], [159], [160]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[167], [168], [7]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[167], [168], [7]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[167], [168], [7]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[7], [139]
Pharmacodynamic antagonistic effects
	Antagonize the effect of cholinergic agents					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0015		Acetylcholine	C7H16NO2+	187	Moderate		Inter Info	[115], [116]
D0256		Carbamoylcholine (ophthalmic)	C6H15N2O2+	2551	Moderate		Inter Info	[115], [116]
D0440		Demecarium (ophthalmic)	C32H52N4O4+2	5966	Moderate		Inter Info	[115], [116]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[132], [133], [134], [135], [136], [137]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[115], [116]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[132], [133], [134], [135], [136], [137]
D0856		Isoflurophate (ophthalmic)	C6H14FO3P	5936	Moderate		Inter Info	[115], [116]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[132], [133], [134], [135], [136], [137]
D1286		Physostigmine (ophthalmic)	C15H21N3O2	5983	Moderate		Inter Info	[115], [116]
D1289		Pilocarpine (ophthalmic)	C11H16N2O2	5910	Moderate		Inter Info	[115], [116]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[132], [133], [134], [135], [136], [137]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[132], [133], [134], [135], [136], [137]
	Antagonize the effect of dopaminergic agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[121]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[95], [96], [69], [97], [98], [99], [100], [43], [101], [70], [71], [3], [4], [102], [103], [104]
	Antagonize the effects of neuroleptic agents					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[86], [91], [76]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[76], [124], [87], [125], [91], [86], [74], [83], [77], [126], [127], [80], [82], [75], [128], [81], [79], [78], [84], [129], [85]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[76], [124], [87], [78], [86], [126], [80], [125], [75], [79], [84], [74], [129], [77], [85], [128], [91], [83], [127], [82], [81]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[76], [124], [87], [125], [91], [86], [74], [83], [77], [126], [127], [80], [82], [75], [128], [81], [79], [78], [84], [129], [85]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[76], [124], [87], [125], [91], [86], [74], [83], [77], [126], [127], [80], [82], [75], [128], [81], [79], [78], [84], [129], [85]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[6], [3], [138]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[6], [3], [138]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[6], [3], [138]

References
1	Cerner Multum, Inc. "Canadian Product Information.".
2	Product Information. Versacloz (cloZAPine). Jazz Pharmaceuticals, Palo Alto, CA.
3	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
4	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
5	Cerner Multum, Inc. "Australian Product Information.".
6	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
7	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8	US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
9	Product Information. FazaClo (cloZAPine). Jazz Pharmaceuticals, Palo Alto, CA.
10	US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines requires its strongest warning.".
11	Sekar M, Mimpriss TJ "Buprenorphine, benzodiazepines and prolonged respiratory depression." Anaesthesia 42 (1987): 567-8. [PMID: 3592200]
12	Pirnay S, Borron SW, Giudicelli CP, Tourneau J, Baud FJ, Ricordel I "A critical review of the causes of death among post-morten toxicological investigations: analysis of 34 buprenorphine-associated and 35 methadone-associated deaths." Addiction 99 (2004): 978-88. [PMID: 15265095]
13	Schuman-Olivier Z, Hoeppner BB, Weiss RD, Borodovsky J, Shaffer HJ, Albanese MJ "Benzodiazepine use during buprenorphine treatment for opioid dependence: clinical and safety outcomes." Drug Alcohol Depend 132 (2013): 580-6. [PMID: 23688843]
14	Reynaud M, Petit G, Potard D, Courty P "Six deaths linked to concomitant use of buprenorphine and benzodiazepines." Addiction 93 (1998): 1385-92. [PMID: 9926544]
15	Kintz P "A new series of 13 buprenorphine-related deaths." Clin Biochem 35 (2002): 513-6. [PMID: 12493578]
16	Kilicarslan T, Sellers EM "Lack of interaction of buprenorphine with flunitrazepam metabolism." Am J Psychiatry 157 (2000): 1164-6. [PMID: 10873929]
17	Product Information. Suboxone (buprenorphine-naloxone). Reckitt and Colman Pharmaceuticals Inc, Richmond, VA.
18	Reynaud M, Tracqui A, Petit G, Potard D, Courty P "Six deaths linked to misuse of buprenorphine-benzodiazepine combinations." Am J Psychiatry 155 (1998): 448-9. [PMID: 9501765]
19	Hakkinen M, Launiainen T, Vuori E, Ojanpera I "Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoning." Eur J Clin Pharmacol 68 (2012): 301-9. [PMID: 21927835]
20	Gueye PN, Borron SW, Risede P, et al "Buprenorphine and midazolalm act in combination to depress respiration in rats." Toxicol Sci 65 (2002): 107-14. [PMID: 11752690]
21	Tracqui A, Kintz P, Ludes B "Buprenorphine-related deaths among drug addicts in France: a report on 20 fatalities." J Anal Toxicol 22 (1998): 430-4. [PMID: 9788517]
22	Martin HA "The possible consequences of combining lorazepam and buprenorphine/naloxone: a case review." J Emerg Nurs 37 (2011): 200-2. [PMID: 21397143]
23	Center for Substance Abuse Treatment.?Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 2004. [PMID: 22514846]
24	Ferrant O, Papin F, Clin B, et al "Fatal poisoning due to snorting buprenorphine and alcohol consumption." Forensic Sci Int 204 (2011): e8-11. [PMID: 20554411]
25	Kintz P "Deaths involving buprenorphine: a compendium of French cases." Forensic Sci Int 121 (2001): 65-9. [PMID: 11516889]
26	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
27	Hansen BS, Dam M, Brandt J, et al "Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man." Acta Neurol Scand 61 (1980): 357-67. [PMID: 6998251]
28	Peterson GR, Covault HP, Hostetler RM "Acute inhibition of microsomal drug metabolism by propoxphene in narcotic tolerant/dependent mice." Life Sci 22 (1978): 2087-96. [PMID: 566834]
29	Abernethy DR, Greenblatt DJ, Morse DS, Shader RI "Interaction of propoxyphene with diazepam, alprazolam and lorazepam." Br J Clin Pharmacol 19 (1985): 51-7. [PMID: 2858217]
30	Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
31	Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
32	Hindmarsh T, Grepe A, Widen L "Metrizamide-phenothiazine interaction: report of a case with seizures following myelography." Acta Radiol Diagn (Stockh) 16 (1975): 129-35. [PMID: 810000]
33	Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
34	Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
35	Bateman DN, Rawlins MD, Simpson JM "Extrapyramidal reactions with metoclopramide." Br Med J (Clin Res Ed) 291 (1985): 930-2. [PMID: 3929968]
36	Ganzini L, Casey DE, Hoffman WF, McCall AL "The prevalence of metoclopramide-induced tardive dyskinesia and acute extrapyramidal movement disorders." Arch Intern Med 153 (1993): 1469-75. [PMID: 8512437]
37	Grimes JD "Parkinsonism and tardive dyskinesia associated with long-term metoclopramide therapy." N Engl J Med 305 (1981): 1417. [PMID: 7300862]
38	JimenezJimenez FJ, GarciaRuiz PJ, Molina JA "Drug-induced movement disorders." Drug Saf 16 (1997): 180-204. [PMID: 9098656]
39	Kenney C, Hunter C, Davidson A, Jankovic J "Metoclopramide, an Increasingly Recognized Cause of Tardive Dyskinesia." J Clin Pharmacol (2008):. [PMID: 18223146]
40	Lata PF, Pigarelli DL "Chronic metoclopramide therapy for diabetic gastroparesis." Ann Pharmacother 37 (2003): 122-6. [PMID: 12503946]
41	Lavy S, Melamed E, Penchas S "Tardive dyskinesia associated with metoclopramide." Br Med J 1 (1978): 77-8. [PMID: 620205]
42	Matson JL, Mayville EA, Bielecki J, Smalls Y, Eckholdt CS "Tardive dyskinesia associated with metoclopramide in persons with developmental disabilities." Res Dev Disabil 23 (2002): 224-33. [PMID: 12102590]
43	Product Information. Reglan (metoclopramide). Wyeth-Ayerst Laboratories, Philadelphia, PA.
44	Putnam PE, Orenstein SR, Wessel HB, Stowe RM "Tardive dyskinesia associated with use of metoclopramide in a child." J Pediatr 121 (1992): 983-5. [PMID: 1447672]
45	Sewell DD, Kodsi AB, Caligiuri MP, Jeste DV "Metoclopramide and tardive dyskinesia." Biol Psychiatry 36 (1994): 630-2. [PMID: 7833431]
46	Skidmore F, Reich SG "Tardive Dystonia." Curr Treat Options Neurol 7 (2005): 231-236. [PMID: 15814076]
47	Srinivasan K, Mouli KS, Viegas B, Khan MF, Vas M "Metoclopramide induced tardive dyskinesia." J Indian Med Assoc 89 (1991): 260-1. [PMID: 1795112]
48	Stewart RB, Cerda JJ, Moore MT, Hale WE "Metoclopramide: an analysis of inappropriate long-term use in the elderly." Ann Pharmacother 26 (1992): 977-9. [PMID: 1504411]
49	Farquharson-Roberts MA, Giddings AE, Nunn AJ "Perforation of small bowel due to slow release potassium chloride (slow-K)." Br Med J 3 (1975): 206. [PMID: 1148734]
50	Lambert JR, Newman A "Ulceration and stricture of the esophagus due to oral potassium chloride (slow release tablet) therapy." Am J Gastroenterol 73 (1980): 508-11. [PMID: 7424872]
51	Lofgren RP, Rothe PR, Carlson GJ "Jejunal perforation associated with slow-release potassium chloride therapy." South Med J 75 (1982): 1154-5. [PMID: 7123349]
52	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
53	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
54	Burke RE, Fahn S, Mayeux R, Weinberg H, Louis K, Willner JH "Neuroleptic malignant syndrome caused by dopamine-depleting drugs in a patient with Huntington disease." Neurology 31 (1981): 1022-5. [PMID: 6115336]
55	Login IS, Cronin MJ, MacLeod RM "Neuroleptic malignant syndrome caused by dopamine depleting drugs." Neurology 32 (1982): 1022-5. [PMID: 6119652]
56	Mateo D, Munoz-Blanco JL, Gimenez-Roldan S "Neuroleptic malignant syndrome related to tetrabenazine introduction and haloperidol discontinuation in Huntington's disease." Clin Neuropharmacol 15 (1992): 63-8. [PMID: 1533561]
57	Moss JH, Stewart DE "Iatrogenic parkinsonism in Huntington's chorea." Can J Psychiatry 31 (1986): 865-6. [PMID: 2948633]
58	Ossemann M, Sindic CJ, Laterre C "Tetrabenazine as a cause of neuroleptic malignant syndrome." Mov Disord 11 (1996): 95. [PMID: 8771075]
59	Petzinger GM, Bressman SB "A case of tetrabenazine-induced neuroleptic malignant syndrome after prolonged treatment." Mov Disord 12 (1997): 246-8. [PMID: 9087987]
60	Product Information. Nitoman (tetrabenazine). Cambridge Laboratories Ltd, Wallsend, Tyne & Wear, .
61	Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
62	Stevens E, Roman A, Houa M, Razavi D, Jaspar N "Severe hyperthermia during tetrabenazine therapy for tardive dyskenesia." Intensive Care Med 24 (1998): 369-71. [PMID: 9609418]
63	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
64	Product Information. Topamax (topiramate). Ortho Pharmaceutical Corporation, Raritan, NJ.
65	Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
66	Fruncillo R, Gibbons W, Vlasses P, Ferguson R "Severe hypotension associated with concurrent clonidine and antipsychotic medication." Am J Psychiatry 142 (1985): 274. [PMID: 2857531]
67	Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9. [PMID: 7663034]
68	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
69	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
70	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
71	Product Information. Risperdal (risperidone). Janssen Pharmaceutica, Titusville, NJ.
72	White WB "Hypotension with postural syncope secondary to the combination of chlorpromazine and captopril." Arch Intern Med 146 (1986): 1833-4. [PMID: 3530167]
73	Cohen MA, Alfonso CA, Mosquera M. Development of urinary retention during treatment with clozapine and meclizine [published correction appears in Am J Psychiatry 1994 Jun;151(6):952]. Am J Psychiatry. 1994;151(4):619-620. [PMID: 8147469]
74	Forester D "Fatal drug-induced heat stroke." JACEP 7 (1978): 243-4. [PMID: 661049]
75	Gershon S, Neubauer H, Sundland DM "Interaction between some anticholinergic agents and phenothiazines." Clin Pharmacol Ther 6 (1965): 749-56. [PMID: 4378954]
76	Hvizdos AJ, Bennett JA, Wells BG, Rappaport KB, Mendel SA "Anticholinergic psychosis in a patient receiving usual doses of haloperidol." Clin Pharm 2 (1983): 174-8. [PMID: 6883947]
77	Johnson AL, Hollister LE, Berger PA "The anticholinergic intoxication syndrome: diagnosis and treatment." J Clin Psychiatry 42 (1981): 313-7. [PMID: 7251568]
78	Kulik AV, Wilbur R "Delirium and stereotypy from anticholinergic antiparkinson drugs." Prog Neuropsychopharmacol Biol Psychiatry 6 (1982): 75-82. [PMID: 7202232]
79	Lee BS "Possibility of hyperpyrexia with antipsychotic and anticholinergic drugs." J Clin Psychiatry 47 (1986): 571. [PMID: 3771507]
80	Mann SC, Boger WP "Psychotropic drugs, summer heat and humidity, and hyperplexia: a danger restated." Am J Psychiatry 135 (1978): 1097-100. [PMID: 29501]
81	Moreau A, Jones BD, Banno V "Chronic central anticholinergic toxicity in manic depressive illness mimicking dementia." Can J Psychiatry 31 (1986): 339-41. [PMID: 3708528]
82	Product Information. Artane (trihexyphenidyl). Lederle Laboratories, Wayne, NJ.
83	Product Information. Cogentin (benztropine). Merck & Co, Inc, West Point, PA.
84	Sarnquist F, Larson CP Jr "Drug-induced heat stroke." Anesthesiology 39 (1973): 348-50. [PMID: 4728582]
85	Stadnyk AN, Glezos JD "Drug-induced heat stroke." Can Med Assoc J 128 (1983): 957-9. [PMID: 6831343]
86	Warnes H, Lehmann HE, Ban TA "Adynamic ileus during psychoactive medication: a report of three fatal and five severe cases." Can Med Assoc J 96 (1967): 1112-3. [PMID: 6021058]
87	Zelman S, Guillan R "Heat stroke in phenothiazine-treated patients: a report of three fatalities." Am J Psychiatry 126 (1970): 1787-90. [PMID: 5441734]
88	Divoll M, Greenblatt DJ, Lacasse Y, Shader RI "Benzodiazepine overdosage: plasma concentrations and clinical outcome." Psychopharmacology (Berl) 73 (1981): 381-3. [PMID: 6789361]
89	Grabowski BS, Cady WJ, Young WW, Emery JF "Effects of acute alcohol administration on propranolol absorption." Int J Clin Pharmacol Ther Toxicol 18 (1980): 317-9. [PMID: 7429677]
90	Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
91	Byerly MJ, Christensen RC, Evans DL "Delirium associated with a combination of sertraline, haloperidol, and benztropine." Am J Psychiatry 153 (1996): 965-6. [PMID: 8659626]
92	Product Information. Botox (onabotulinumtoxin A). Allergan Inc, Irvine, CA.
93	Product Information. Myobloc (botulinum toxin type B) Elan Pharmaceuticals, S. San Francisco, CA.
94	Product Information. Xeomin (botulinum toxin type A (obsolete) (botulinum toxin type A)). Merz Pharmaceuticals, Greensboro, NC.
95	Mims RB, Scott CL, Modebe O, Bethune JE "Inhibition of L-dopa-induced growth hormone stimulation by pyridoxine and chlorpromazine." J Clin Endocrinol Metab 40 (1975): 256-9. [PMID: 1117978]
96	Product Information. Dostinex (cabergoline). Pharmacia and Upjohn, Kalamazoo, MI.
97	Product Information. Mirapex (pramipexole). Boehringer Ingelheim, Ridgefield, CT.
98	Product Information. Norprolac (quinagolide). Ferring Inc, North York, IA.
99	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
100	Product Information. Permax (pergolide). Athena Neurosciences Inc, South San Francisco, CA.
101	Product Information. Requip (ropinirole). SmithKline Beecham, Philadelphia, PA.
102	Robbins RJ, Kern PA, Thompson TL "Interactions between thioridazine and bromocriptine in a patient with a prolactin-secreting pituitary adenoma." Am J Med 76 (1984): 921-3. [PMID: 6720732]
103	Weingarten JC, Thompson TL "The effect of thioridazine on prolactinoma growth in a schizophrenic man: case report." Gen Hosp Psychiatry 7 (1985): 364-6. [PMID: 4065553]
104	Yahr MD, Duvoisin RC "Drug therapy of parkinsonism." N Engl J Med 287 (1972): 20-4. [PMID: 4555145]
105	Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
106	Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
107	Cole JM, Sheehan AH, Jordan JK "Concomitant use of ipratropium and tiotropium in chronic obstructive plmonary disease." Ann Pharmacother 46 (2012): 1717-21. [PMID: 23170031]
108	Product Information. Anoro Ellipta (umeclidinium-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
109	Product Information. Atrovent (ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
110	Product Information. Combivent (albuterol-ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
111	Product Information. Qbrexza (glycopyrrolate topical). Dermira, Inc., Menlo Park, CA.
112	Product Information. Spiriva (tiotropium). Boehringer Ingelheim, Ridgefield, CT.
113	Product Information. Tudorza Pressair (aclidinium). Forest Pharmaceuticals, St. Louis, MO.
114	Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
115	Multum Information Services, Inc. Expert Review Panel.
116	Product Information. Pilopine HS (pilocarpine ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
117	Postma JU, van Tilburg W "Visual hallucinations and delirium during treatment with amantadine (Symmetrel)." J Am Geriatr Soc 23 (1975): 212-5. [PMID: 123540]
118	Product Information. Symmetrel (amantadine). DuPont Pharmaceuticals, Wilmington, DE.
119	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
120	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
121	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
122	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
123	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
124	Rockland L, Cooper T, Schwartz F, Weber D, Sullivan T "Effects of trihexyphenidyl on plasma chlorpromazine in young schizophrenics." Can J Psychiatry 35 (1990): 604-7. [PMID: 2268840]
125	Kwok JS, Chan TY "Recurrent heat-related illnesses during antipsychotic treatment." Ann Pharmacother 39 (2005): 1940-2. [PMID: 16174785]
126	Roth A, Akyol S, Nelson JC "Delirium associated with the combination of a neuroleptic, an SSRI, and benztropine." J Clin Psychiatry 55 (1994): 492-5. [PMID: 7989283]
127	Hansen LB, Elley J, Christensen TR, Larsen NE, Naestoft J, Hvidberg EF "Plasma levels of perphenazine and its major metabolites during simultaneous treatment with anticholinergic drugs." Br J Clin Pharmacol 7 (1979): 75-80. [PMID: 760745]
128	Rivera-Calimlim L, Nasrallah H, Strauss J, Lasagna L "Clinical response and plasma levels: effect of dose, dosage schedules, and drug interactions on plasma chlorpromazine levels." Am J Psychiatry 133 (1976): 646-52. [PMID: 5901]
129	Singh MM, Kay SR "Therapeutic antagonism between anticholinergic antiparkinsonism agents and neuroleptics in schizophrenia: implications for a neuropharmacological model." Neuropsychobiology 5 (1979): 74-86. [PMID: 34804]
130	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
131	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
132	Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC "Explicit criteria for determining inappropriate medication use in nursing home residents." Arch Intern Med 151 (1991): 1825-32. [PMID: 1888249]
133	Carnahan RM, Lund BC, Perry PJ, Chrischilles EA "The concurrent use of anticholinergics and cholinesterase inhibitors: rare event or common practice?" J Am Geriatr Soc 52 (2004): 2082-7. [PMID: 15571547]
134	Edwards KR, O'Connor JT "Risk of delirium with concomitant use of tolterodine and acetylcholinesterase inhibitors." J Am Geriatr Soc 50 (2002): 1165-6. [PMID: 12110086]
135	Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH "Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts." Arch Intern Med 163 (2003): 2716-2724. [PMID: 14662625]
136	Katz IR, Sands LP, Bilker W, DiFilippo S, Boyce A, D'Angelo K "Identification of medications that cause cognitive impairment in older people: the case of oxybutynin chloride." J Am Geriatr Soc 46 (1998): 8-13. [PMID: 9434659]
137	Roe CM, Anderson MJ, Spivack B "Use of anticholinergic medications by older adults with dementia." J Am Geriatr Soc 50 (2002): 836-42. [PMID: 12028169]
138	Product Information. Loxitane C Oral Concentrate (loxapine) Watson Laboratories Inc, Corona, CA.
139	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
140	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
141	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
142	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
143	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
144	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
145	Kajiyama Y, Fujii K, Takeuchi H, Manabe Y "Ginkgo seed poisoning." Pediatrics 109 (2002): 325-7. [PMID: 11826216]
146	Granger AS "Ginkgo biloba precipitating epileptic seizures." Age Ageing 30 (2001): 523-5. [PMID: 11742783]
147	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
148	Spinella M "Herbal medicines and epilepsy: the potential for benefit and adverse effects." Epilepsy Behav 2 (2001): 524-32. [PMID: 12609386]
149	Gregory PJ "Seizure associated with Ginkgo biloba?." Ann Intern Med 134 (2001): 344. [PMID: 11182853]
150	Harms SL, Garrard J, Schwinghammer P, Eberly LE, Chang Y, Leppik IE "Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder." Epilepsia 47 (2006): 323-9. [PMID: 16499756]
151	Miwa H, Iijima M, Tanaka S, Mizuno Y "Generalized convulsions after consuming a large amount of Gingko nuts." Epilepsia 42 (2001): 280-1. [PMID: 11240603]
152	Kupiec T, Raj V "Fatal seizures due to potential herb-drug interactions with Ginkgo biloba." J Anal Toxicol 29 (2005): 755-8. [PMID: 16419414]
153	Product Information. Ifex (ifosfamide). Bristol-Myers Squibb, Princeton, NJ.
154	Simonian NA, Gilliam FG, Chiappa KH "Ifosfamide causes a diazepam-sensitive encephalopathy." Neurology 43 (1993): 2700-2
155	Product Information. AdreView (iobenguane I-123). GE Healthcare, Princeton, NJ.
156	Product Information. DaTscan (ioflupane I-123). GE Healthcare, Princeton, NJ.
157	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
158	Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
159	Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
160	Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.
161	Swanson CL, Price WA, Mcevoy JP "Effects of concomitant risperidone and lithium treatment." Am J Psychiatry 152 (1995): 1096. [PMID: 7540798]
162	Goldman SA "FDA medwatch report: lithium and neuroleptics in combination: the spectrum of neurotoxicity." Psychopharmacol Bull 32 (1996): 299-309. [PMID: 8961772]
163	Eronen M, Putkonen H, Hallikainen T, Vartiainen H "Lethal gastroenteritis associated with clozapine and loperamide." Am J Psychiatry 160 (2003): 2242-2243. [PMID: 14638602]
164	Product Information. Belviq (lorcaserin). Eisai Inc, Teaneck, NJ.
165	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
166	Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
167	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
168	Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]
169	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
170	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
171	Product Information. Atrovent nasal spray (ipratropium nasal). Boehringer-Ingelheim, Ridgefield, CT.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence