Drug General Information (ID: DDIDL3X0Q1)
Drug Name			Didanosine		Drug Info		Rifampicin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antituberculosis Agents
Structure

Mechanism of Didanosine-Rifampicin Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Didanosine				Rifampicin
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Didanosine due to altered gastric pH caused by Rifampicin

Recommended Action
Management		Rifampin should be administered at least 1 hour before antacids. Monitoring for altered therapeutic effect is advisable.

References
1	Product Information. Rifadin (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.