Drug General Information (ID: DDICV10N97)
Drug Name			Amphetamine		Drug Info		Ethanol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Analgesics
Structure

Mechanism of Amphetamine-Ethanol Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Amphetamine				Ethanol
Mechanism		Amphetamines				Potentiate the cardiovascular effects of amphetamines
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Amphetamine and Ethanol

Recommended Action
Management		Concomitant use of amphetamines and ethanol should be avoided if possible, especially in patients with a history of heart disease.

References
1	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
2	Jiao X, Velez S, Ringstad J, Eyma V, Miller D, Bleiberg M "Myocardial infarction associated with Adderall XR and alcohol use in a young man." J Am Board Fam Med 22 (2009): 197-201