Drug General Information (ID: DDICF6X05V)
Drug Name			Amphotericin B (liposomal)		Drug Info		Pentamidine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antifungal Agents				Antifungal Agents
Structure

Mechanism of Amphotericin B (liposomal)-Pentamidine Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Amphotericin B (liposomal)				Pentamidine
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Amphotericin B (liposomal) and Pentamidine

Recommended Action
Management		Serum creatinine and BUN should be monitored closely during therapy with these two agents.

References
1	Antoniskis D, Larsen RA "Acute, rapidly progressive renal failure with simultaneous use of amphotericin B and pentamidine." Antimicrob Agents Chemother 34 (1990): 470-2. [PMID: 2334159]
2	Product Information. Abelcet (amphotericin B). Liposome Company Inc, The, Princeton, NJ.