Details of Drug

Drug General Information (ID: D1246)
Drug Name	Pentamidine
Drug Type	Small molecule
Drug Synonymous	Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (Isethionate); Pentacarinat (Isethionate); Pentam 300 (Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide Click to Show/Hide
Disease Class	1F29-1F2F: Fungal infection; 1C60-1C62: Human immunodeficiency virus disease
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C19H24N4O2
InChI	1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
InChIKey	XDRYMKDFEDOLFX-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
External Link
	Pubchem ID	4735
	CAS Number	100-33-4
	CHEBI ID	45081
	TTD ID	D05EAM
	VARIDT ID	DR00085

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM027 Decreased renal excretion due to nephrotoxicity BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM049 Increased risk of atrioventricular block BM063 Increased risk of hypocalcemia BM064 Increased risk of hypoglycemia BM066 Increased risk of hypomagnesemia BM072 Increased risk of nephrotoxicity BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM100 Antagonize the effect of vaccine/toxoid BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Pentamidine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[283], [284], [285]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[256]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[258]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[275]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[319]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[270]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[326]
	Additive hypotensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[1], [2], [3], [293], [48]
	Additive immunosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[3], [29]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[193]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[297]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[316]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[325]
	Additive myelosuppressive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[30], [31]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[2], [109], [110]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[2], [3], [277], [278]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[2], [3], [277], [278]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[3], [126], [250]
	Increased risk of hypocalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[51], [52], [53]
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[3]
	Increased risk of hypomagnesemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[199]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[199]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[199]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[199]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[199]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[199]
	Increased risk of nephrotoxicity					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[25]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[64], [65], [66]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[107], [108]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[117], [118], [119]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[64], [65], [66]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[64], [65], [66]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[64], [65], [66]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[34], [35], [36]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[117], [118], [119]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[117], [118], [119]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[117], [118], [119]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[195], [196]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[195], [196]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[195], [196]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[195], [196]
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[2], [3]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[198]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[251], [252], [253]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[257], [206], [213]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[266], [251], [252], [253]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[257], [206], [213]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[2], [3]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[3]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[266], [251], [252], [253]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[2], [3]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[266], [251], [252], [253]
D1672		Valaciclovir	C13H20N6O4	135398742	Moderate		Inter Info	[3], [337]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[2], [3]
	Increased risk of prolong QT interval					Drug Num: 173
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2], [3], [4]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[6], [3], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[1], [2], [3], [26], [27], [28]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3], [49]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[50]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[54], [1], [2], [3], [55], [56], [57]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[1], [2], [3], [58], [59], [60], [61], [62], [63], [48]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[1], [2], [3], [67]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[1], [2], [3], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [48]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[78], [54], [79], [1], [2], [3], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[2], [3], [100]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[103]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[3], [104]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3], [105]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[106]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1], [2], [3], [112]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3], [113]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [114], [2], [3], [115], [116], [48]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[78], [54], [79], [1], [2], [3], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[122], [1], [2], [3], [123], [124], [125], [126], [127]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[6], [3], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [2], [3], [128], [48]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[131]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[132]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [133], [48]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[2], [3], [134]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[135]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[1], [2], [3], [136], [48]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2], [3], [137]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1], [2], [3], [31]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[138]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[140]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[141], [142], [143], [144], [145], [146], [147], [148]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3], [149]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [150], [151], [48]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1], [2], [3], [150], [84], [152], [153], [48]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[154], [155], [1], [2], [3], [156], [157]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[3], [158]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[54], [1], [2], [3], [160], [161], [82], [84], [86], [162], [87], [88], [163], [90], [91], [92], [93], [164], [97], [57], [165]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[1], [2], [3], [168]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3], [169]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[1], [2], [3], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[1], [2], [3], [171], [150], [172], [173], [174], [48]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[1], [2], [3], [175]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[1], [2], [3], [150], [176], [48]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[1], [2], [3], [194], [48]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[1], [2], [3], [197], [48]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[84], [153], [48]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[84], [153], [48]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[254]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[2], [3], [255]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[84], [153], [48]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[2], [3], [259], [260], [261], [262], [263], [264]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1], [2], [3], [265], [48]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[3], [267]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[268]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[269]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[84], [153], [48]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[271]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[2], [3], [272]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[1], [2], [3], [273]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[2], [3], [274]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[276]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[54], [86], [87], [92], [279]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[280]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[281]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[3], [282]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[54], [1], [2], [3], [82], [83], [84], [286], [287], [87], [88], [288], [89], [289], [90], [91], [92], [93], [290], [291], [292], [97], [57]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[294], [295]
D0948		Lopinavir	C37H48N4O5	92727	Moderate		Inter Info	[1], [2], [296]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[54], [1], [2], [3], [82], [83], [84], [286], [287], [87], [88], [288], [89], [289], [90], [91], [92], [93], [290], [291], [292], [97], [57]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[54], [1], [2], [3], [82], [83], [84], [286], [287], [87], [88], [288], [89], [289], [90], [91], [92], [93], [290], [291], [292], [97], [57]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[3], [298]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[301]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[302], [303], [304], [305], [306], [307], [308], [309], [310], [311]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1], [2], [3], [150], [312], [313], [314], [315], [48]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[1], [2], [3], [317]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[1], [2], [3], [318]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1], [2], [3], [320], [321], [322]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[1], [2], [3], [323], [48]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[3], [177], [178], [179], [180], [181], [182], [183]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[327], [328]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[329], [330]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[1], [2], [3], [331]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[332], [333], [259], [334], [335], [336], [48]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1], [2], [3], [150], [84], [153], [48]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[2], [338], [339], [340]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[1], [2], [3], [341], [342], [343], [344]
	Increased risk of ventricular arrhythmias					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[101], [102]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[1], [2], [3], [120], [121]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[3], [129], [130]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[139]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[2], [159]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[1], [187], [2], [3], [188], [189], [190], [26], [191], [192]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[1], [2], [3], [200], [201], [202]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[1], [2], [3], [200], [201], [202]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[2], [3], [249]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[230], [240], [243]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[230], [240], [243]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[230], [240], [243]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[1], [2], [3], [247], [248], [249]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[3], [299], [300]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[3], [299], [300]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[2], [3], [249]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[1], [2], [3], [200], [201], [202]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[230], [240], [243]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[3], [299], [300]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2], [3], [324]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[230], [240], [243]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[1], [2], [3], [200], [201], [202]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[3], [5]
D0483		Didanosine	C10H12N4O3	135398739	Major		Inter Info	[2], [3], [111]
D1715		Zalcitabine	C9H13N3O3	24066	Major		Inter Info	[2], [3], [111]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[184], [185], [186]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[184], [185], [186]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[184], [185], [186]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[184], [185], [186]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[184], [185], [186]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[184], [185], [186]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[186], [215], [216]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[184], [185], [186]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[184], [185], [186]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[184], [185], [186]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[184], [185], [186]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[184], [185], [186]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[184], [185], [186]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[184], [185], [186]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[184], [185], [186]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[184], [185], [186]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[184], [185], [186]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[184], [185], [186]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[184], [185], [186]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[184], [185], [186]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[184], [185], [186]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[184], [185], [186]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[184], [185], [186]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[184], [185], [186]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[184], [185], [186]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[184], [185], [186]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[184], [185], [186]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[184], [185], [186]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[184], [185], [186]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[184], [185], [186]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[184], [185], [186]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[184], [185], [186]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[184], [185], [186]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[184], [185], [186]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[184], [185], [186]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[184], [185], [186]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[184], [185], [186]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[184], [185], [186]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[184], [185], [186]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[184], [185], [186]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[184], [185], [186]
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[3], [166], [167]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[170]

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
5	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
6	Harper KM, Knapp DJ, Criswell HE, Breese GR "Vasopressin and alcohol: A multifaceted relationship." Psychopharmacology (Berl) 235 (2018): 3363-79. [PMID: 32936259]
7	Javelot H, El-Hage W, Meyer G, Becker G, Michel B, Hingray C "COVID-19 and (hydroxy)chloroquine-azithromycin combination: should we take the risk for our patients?" Br J Clin Pharmacol Apr 29 (2020): epub ahead of print. [PMID: 32350872]
8	National Institutes of Health (NIH) "Coronavirus Disease 2019 (COVID-19) Treatment Guidelines.".
9	Product Information. Chloroquine Phosphate (chloroquine). West-Ward Pharmaceutical Corporation, Eatontown, NJ.
10	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
11	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
12	Roden DM, Harrington RA, Poppas A, Russo AM "Considerations for drug interactions on QTc in exploratory COVID-19 (Coroanvirus disease 2019) treatment." Heart Rhythm Apr 14 (2020): epub ahead of print. [PMID: 32302703]
13	Sacher F, Fauchier L, Boveda S, et.al "Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 infection." Arch Cardiovasc Dis Apr 24 (2020): epub ahead of print. [PMID: 32354666]
14	Saleh M, Gabriels J, ChangD, et.al "The effect of chloroquine, hydroxychloroquine and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection." Circ Arrhythm Electrophysiol Apr 29 (2020): epub ahead of print. [PMID: 32347743]
15	Sapp JL, Alqarawi W, MacIntyre CJ, et.al "Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: A statement from the Canadian Heart Rhythm Society." Can J Cardiol Apr 8 (2020): epub ahead of print. [PMID: 32299753]
16	Smit C, Peeters MYM, van den Anker JN, Knibbe CAJ "Chloroquine for SARS-CoV-2: Implications of its unique pharmacokinetic and safety properties." Clin Pharmacokinet Ar 18 (2020): epub ahead of print. [PMID: 32306288]
17	Bessiere F, Roccia H, Deliniere A, et.al "Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit." JAMA Cardiol May 1 (2020): epub ahead of print. [PMID: 32936266]
18	Borba MGS, Val FFA, Sampaio VS, et.al "Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 1 (SARS-CoV-2) infection: A randomized clinical trial." JAMA Netw Open Apr 1 (2020): epub ahead of print. [PMID: 32330277]
19	Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ "Urgent guidance for navigating and circumventing the QTc-prolonging and torsadogenic potential of possible pharmacotherapies for coronavirus disease 19 (COVID-19)" Mayo Clin Proc Apr 7 (2020): epub ahead of print. [PMID: 32359771]
20	Kapoor A, Pandurangi U, Arora V, et.al "Cardiovascular risks of hydroxychloroquine in treatment and prophylaxis of COVID-19 patients: A scientific statement from the Indian Heart Rhythm Society." Indian Pacing Electorphysiol J Apr 8 (2020): epub ahead of print. [PMID: 32278018]
21	Mercuro NJ, Yen CF, Shim DJ, et.al "Risk of QT interval prolongation associated with the use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)" JAMA Cardiol May 1:e201834 (2020): epub ahead of print. [PMID: 32936252]
22	mitra RL, Greenstein SA, Epstein lm "An algorithm for managing QT prolongation in coronavirus disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin Possible benefits of intravenous lidocaine." HeartRythm Case Rep Apr 1 (2020): epub ahead of print. [PMID: 32363145]
23	US Food and Drug Administration "FACT SHEET FOR HEALTH CARE PROVIDERS EMERGENCY USE AUTHORIZATION (EUA) OF CHLOROQUINE PHOSPHATE SUPPLIED FROM THE STRATEGIC NATIONAL STOCKPILE FOR TREATMENT OF COVID-19 IN CERTAIN HOSPITALIZED PATIENTS. Available from: URL: https://www.fda.gov/media/13653" ([2020, Apr 27]):.
24	US Food and Drug Administration "Hydroxychloroquine or Chloroquine for COVID-19: Drug Safety Communication - FDA Cautions Against Use Outside of the Hospital Setting or a Clinical Trial Due to Risk of Heart Rhythm Problems.".
25	Product Information. Vistide (cidofovir). Gilead Sciences, Foster City, CA.
26	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
27	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
28	Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251. [PMID: 10084425]
29	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
30	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
31	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
32	Wong GT, Lee EY, Irwin MG. Contrast induced nephropathy in vascular surgery.?Br J Anaesth. 2016;117 Suppl 2:ii63-ii73. [PMID: 27566809]
33	Bennett WM, Porter GA "Nephrotoxicity of common drugs used by urologists." Urol Clin North Am 17 (1990): 145-56. [PMID: 2407013]
34	Bentley ML, Corwin HL, Dasta J "Drug-induced acute kidney injury in the critically ill adult: recognition and prevention strategies." Crit Care Med 38(6 Suppl) (2010): S169-74. [PMID: 20502171]
35	Dubrovskaya Y, Prasad N, Lee Y, Esaian D, Figueroa DA, Tam VH "Risk factors for nephrotoxicity onset associated with polymyxin B therapy." J Antimicrob Chemother 70 (2015): 1903-7. [PMID: 25652747]
36	Kellum JA, Leblanc M, Venkataraman R "Acute renal failure." BMJ Clin Evid 9 (2008): 2001. [PMID: 19445797]
37	Marcos LA, Camins BC, Ritchie DJ, Casabar E, Warren DK "Acute renal insufficiency during telavancin therapy in clinical practice." J Antimicrob Chemother 67 (2012): 723-6. [PMID: 22174040]
38	van den Berk G, Tonino S, de Fijter C, Smit W, Schultz MJ "Bench-to-bedside review: Preventative measures for contrast-induced nephropathy in critically ill patients." Crit Care 9 (2005): 361-70. [PMID: 16137385]
39	Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6. [PMID: 17106497]
40	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
41	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
42	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
43	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
44	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
45	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
46	Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32. [PMID: 11144659]
47	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
48	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
49	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
50	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
51	Foscarnet: a review. Drugs 41 (1991): 106-29. [PMID: 1706982]
52	Product Information. Foscavir (foscarnet). Astra USA, Westborough, MA.
53	Youle M, Clarbour J, Gazzard B, Chanas A "Severe hypocalcemia in AIDS patients treated with foscarnet and pentamidine." Lancet 1 (1988): 1455-6. [PMID: 2898602]
54	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
55	Lode H, Vogel F, Elies W "Grepafloxacin: A review of its safety profile based on clinical trials and postmarketing surveillance." Clin Ther 21 (1999): 61-74. [PMID: 10090425]
56	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
57	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
58	Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
59	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
60	Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
61	O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
62	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
63	Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
64	Guo X, Nzerue C "How to prevent, recognize, and treat drug-induced nephrotoxicity.".
65	Centers for Disease Control and Prevention (CDC). Renal insufficiency and failure associated with immune globulin intravenous therapy--United States, 1985-1998.?MMWR Morb Mortal Wkly Rep. 1999;48(24):518-521. [PMID: 10401909]
66	Product Information. BabyBIG (botulism immune globulin). FFF Enterprises, Temecula, CA.
67	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
68	De Bels D, Staroukine M, Devriendt J "Torsades de pointes due to methadone." Ann Intern Med 139 (2003): E156. [PMID: 12859181]
69	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
70	Gil M, Sala M, Anguera I, et al. "QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone." Am J Cardiol 92 (2003): 995-7. [PMID: 14556883]
71	Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS "Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes." Pharmacotherapy 23 (2003): 802-5. [PMID: 12820821]
72	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
73	Krantz MJ, Mehler PS "Synthetic opioids and QT prolongation." Arch Intern Med 163 (2003): 1615 author reply 1615. [PMID: 12860589]
74	Martell BA, Arnsten JH, Krantz MJ, Gourevitch MN "Impact of methadone treatment on cardiac repolarization and conduction in opioid users." Am J Cardiol 95 (2005): 915-8. [PMID: 15781034]
75	Mokwe EO, Ositadinma O "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966000]
76	Sala M, Anguera I, Cervantes M "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966001]
77	Walker PW, Klein D, Kasza L "High dose methadone and ventricular arrhythmias: a report of three cases." Pain 103 (2003): 321-4. [PMID: 12791438]
78	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
79	Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
80	Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
81	Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
82	Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
83	Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
84	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
85	Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
86	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
87	Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
88	Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
89	Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
90	Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
91	Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
92	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
93	Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
94	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
95	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
96	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
97	Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
98	Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
99	White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
100	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
101	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
102	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
103	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
104	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
105	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
106	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
107	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
108	Rafat C, Fakhouri F, Ribeil JA, Delarue R, Le Quintrec M "Fanconi Syndrome Due to Deferasirox." Am J Kidney Dis (2009):. [PMID: 19493602]
109	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
110	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
111	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
112	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
113	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
114	Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
115	Do A, Noohi S, Elie D, et al. Health Canada Warning on Citalopram and Escitalopram--Its Effects on Prescribing in Consultation-Liaison Psychiatry.?Psychosomatics. 2016;57(1):57-63. [PMID: 26633294]
116	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
117	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
118	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
119	Sheiner PA, Mor E, Chodoff L, Glabman S, Emre S, Schwartz ME, Miller CM "Acute renal, failure associated with the use of ibuprofen in two liver transplant recipients on FK506." Transplantation 57 (1994): 1132-3. [PMID: 7513099]
120	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
121	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
122	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
123	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
124	Nosten F, ter Kuile FO, Luxemburger C, et al "Cardiac effects of antimalarial treatment with halofantrine." Lancet 341 (1993): 1054-6. [PMID: 8096959]
125	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
126	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
127	Sudden death in a traveler following halofantrine administration--Togo, 2000. MMWR Morb Mortal Wkly Rep 50 (2001): 169-70, 179. [PMID: 11393488]
128	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
129	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
130	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
131	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
132	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
133	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
134	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
135	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
136	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
137	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
138	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
139	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
140	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
141	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
142	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
143	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
144	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
145	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
146	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
147	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
148	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
149	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
150	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
151	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
152	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
153	Witchel HJ, Hancox JC, Nutt DJ "Psychotropic drugs, cardiac arrhythmia, and sudden death." J Clin Psychopharmacol 23 (2003): 58-77. [PMID: 12544377]
154	Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
155	Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
156	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
157	FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
158	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
159	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
160	Demolis JL, Charransol A, Funck-Brentano C, Jaillon P "Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers." Br J Clin Pharmacol 41 (1996): 499-503. [PMID: 8799513]
161	Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
162	Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
163	Lipsky BA, Dorr MB, Magner DJ, Talbot GH "Safety profile of sparfloxacin, a new fluoroquinolone antibiotic." Clin Ther 21 (1999): 148-59. [PMID: 10090432]
164	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
165	Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
166	UK government "Typhoid.".
167	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
168	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
169	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
170	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
171	Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8. [PMID: 5794785]
172	Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53. [PMID: 8941027]
173	Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
174	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
175	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
176	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
177	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
178	Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc, Tarrytown, NY.
179	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
180	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
181	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
182	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
183	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
184	Product Information. Pentam 300 (pentamidine). Fujisawa, Deerfield, IL.
185	Coyle P, Carr AD, Depczynski BB, Chisholm DJ "Diabetes mellitus associated with pentamidine use in HIV-infected patients." Med J Aust 165 (1996): 587-8. [PMID: 8941253]
186	Shen M, Orwoll ES, Conte JE, Prince MJ "Pentamidine-induced pancreatic beta-cell dysfunction." Am J Med 86 (1989): 726-8. [PMID: 2658578]
187	Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
188	Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
189	Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
190	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
191	Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
192	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
193	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
194	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
195	Antoniskis D, Larsen RA "Acute, rapidly progressive renal failure with simultaneous use of amphotericin B and pentamidine." Antimicrob Agents Chemother 34 (1990): 470-2. [PMID: 2334159]
196	Product Information. Abelcet (amphotericin B). Liposome Company Inc, The, Princeton, NJ.
197	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
198	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
199	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
200	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
201	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
202	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
203	Banerjee D, Asif A, Striker L, Preston RA, Bourgoignie JJ, Roth D "Short-term, high-dose pamidronate-induced acute tubular necrosis: The postulated mechanisms of bisphosphonate nephrotoxicity." Am J Kidney Dis 41 (2003): E18. [PMID: 12778436]
204	Chang JT, Green L, Beitz J "Renal failure with the use of zoledronic acid." N Engl J Med 349 (2003): 1676-9 discussion 1676-9. [PMID: 14573746]
205	Janssen Van Doorn K, Neyns B, Van Der Niepen P, Verbeelen D "Pamidronate-related nephrotoxicity (tubulointerstitial nephritis) in a patient with osteolytic bone metastases." Nephron 89 (2001): 467-8. [PMID: 11721169]
206	Kanis JA, Preston CJ, Yates AJ, Percival RC, Mundy KI, Russell RG "Effects of intravenous diphosphonates on renal function." Lancet 1 (1983): 1328. [PMID: 6134112]
207	Lockridge L, Papac RJ, Perazella MA "Pamidronate-associated nephrotoxicity in a patient with Langerhans's histiocytosis." Am J Kidney Dis 40 (2002): E2. [PMID: 12087588]
208	Markowitz GS, Fine PL, Stack JI, et al. "Toxic acute tubular necrosis following treatment with zoledronate (Zometa)." Kidney Int 64 (2003): 281-289. [PMID: 12787420]
209	Osullivan TL, Akbari A, Cadnapaphornchai P "Acute renal failure associated with the administration of parenteral etidronate." Ren Fail 16 (1994): 767-73. [PMID: 7899588]
210	Product Information. Aredia (pamidronate). Novartis Pharmaceuticals, East Hanover, NJ.
211	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
212	Product Information. Ostac (clodronate). Hoffmann-La Roche Limited, Mississauga, IA.
213	Product Information. Zometa (zoledronic acid). Novartis Pharmaceuticals, East Hanover, NJ.
214	Zazgornik J, Grafinger P, Biesenbach G, Hubmann R, Fridrik M "Acute renal failure and alendronate." Nephrol Dial Transplant 12 (1997): 2797-8. [PMID: 9430905]
215	Wood G, Wetzig N, Hogan P, Whitby M "Survival from pentamidine induced pancreatitis and diabetes mellitus." Aust N Z J Med 21 (1991): 341-2
216	Stahl-Bayliss CM, Kalman CM, Laskin OL "Pentamidine-induced hypoglycemia in patients with the acquired immune deficiency syndrome." Clin Pharmacol Ther 39 (1986): 271-5
217	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
218	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
219	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
220	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
221	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
222	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
223	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
224	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
225	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
226	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
227	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
228	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
229	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
230	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
231	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
232	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
233	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
234	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
235	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
236	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
237	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
238	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
239	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
240	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
241	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
242	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
243	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
244	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
245	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
246	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
247	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
248	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
249	Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
250	Canadian Pharmacists Association "e-CPS."
251	Product Information. Canasa (mesalamine (5-aminosalicylic acid)). Axcan Scandipharm Inc, Birmingham, AL.
252	Product Information. Lialda (mesalamine (5-aminosalicylic acid)). Shire US Inc, Florence, KY.
253	Schreiber S. Hamling J, Zehnter E, et al "Renal tubular dysfunction in patients with inflammatory bowel disease treated with aminosalicylate." Gut 40 (1997): 761-6. [PMID: 9245930]
254	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
255	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
256	Product Information. Eloxatin (oxaliplatin). Sanofi Winthrop Pharmaceuticals, New York, NY.
257	Chang JT, Green L, Beitz J "Renal failure with the use of zoledronic acid." N Engl J Med 349 (2003): 1676-9 discussion 1676-9. [PMID: 14573746]
258	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
259	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
260	Kane JM, Carson WH, Saha AR, et al. "Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder." J Clin Psychiatry 63 (2002): 763-71. [PMID: 12363115]
261	Keck PE Jr, Marcus R, Tourkodimitris S, et al. "A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania." Am J Psychiatry 160 (2003): 1651-8. [PMID: 12944341]
262	Nelson S, Leung JG "Torsades de Pointes After Administration of Low-Dose Aripiprazole (February)." Ann Pharmacother (2013):. [PMID: 23362038]
263	Pigott TA, Carson WH, Saha AR, Torbeyns AF, Stock EG, Ingenito GG "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study." J Clin Psychiatry 64 (2003): 1048-56. [PMID: 14628980]
264	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
265	Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
266	Novis BH, Korzets Z, Chen P, Bernheim J "Nephrotic syndrome after treatment with 5-aminosalicylic acid." Br Med J (Clin Res Ed) 296 (1988): 1442. [PMID: 3132281]
267	Abbas R, Hug BA, Leister C, Sonnichsen D "A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects." Int J Cancer 131 (2012): Epub. [PMID: 22065400]
268	Product Information. Lamprene (clofazimine). Novartis Pharmaceuticals, East Hanover, NJ.
269	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
270	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
271	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
272	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
273	Product Information. Halaven (eribulin). Eisai Inc, Teaneck, NJ.
274	Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
275	Product Information. Ancobon (flucytosine). Roche Laboratories, Nutley, NJ.
276	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
277	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
278	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
279	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
280	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
281	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
282	Product Information. Besponsa (inotuzumab ozogamicin). Wyeth Laboratories, Philadelphia, PA.
283	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
284	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
285	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
286	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs. Prolongation of QT interval is probably a class effect of fluoroquinolones." Br Med J 322 (2001): 46-7. [PMID: 11141163]
287	Kahn JB "Latest industry information on the safety profile of levofloxacin in the US." Chemotherapy 47 Suppl 3 (2001): 32-7. [PMID: 11549787]
288	Makaryus AN, Byrns K, Makaryus MN, Natarajan U, Singer C, Goldner B "Effect of ciprofloxacin and levofloxacin on the QT interval: is this a significant "clinical" event?" South Med J 99 (2006): 52-6. [PMID: 16466123]
289	Nykamp DL, Blackmon CL, Schmidt PE, Roberson AG "QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine." Ann Pharmacother 39 (2005): 543-6. [PMID: 15687478]
290	Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
291	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
292	Samaha FF "QTC interval prolongation and polymorphic ventricular tachycardia in association with levofloxacin." Am J Med 107 (1999): 528-9. [PMID: 10569314]
293	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
294	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
295	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
296	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
297	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
298	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
299	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
300	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
301	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
302	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
303	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
304	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
305	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
306	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
307	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
308	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
309	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
310	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
311	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
312	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
313	Sala M, Vicentini A, Brambilla P, et al. "QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy." Ann Gen Psychiatry 4 (2005): 1. [PMID: 15845138]
314	Vieweg WV "New generation antipsychotic drugs and QTc interval prolongation." Prim Care Companion J Clin Psychiatry 5 (2003): 205-15. [PMID: 15213787]
315	Vieweg WV, Schneider RK, Wood MA "Torsade de pointes in a patient with complex medical and psychiatric conditions receiving low-dose quetiapine." Acta Psychiatr Scand 112 (2005): 318-22. [PMID: 16156840]
316	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
317	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
318	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
319	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
320	Demolis JL, Vacheron F, Cardus S, Funck-Brentano C "Effect of single and repeated oral doses of telithromycin on cardiac QT interval in healthy subjects." Clin Pharmacol Ther 73 (2003): 242-52. [PMID: 12621389]
321	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
322	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
323	Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
324	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
325	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
326	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
327	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
328	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
329	European Medicines Agency "CHMP Assessment Report for Latixa. International nonproprietary name: ranolazine.".
330	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
331	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
332	Antonelli D, Atar S, Freedberg NA, Rosenfeld T "Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions." Isr Med Assoc J 7 (2005): 163-5. [PMID: 15792261]
333	Dattilo PB, Nordin C "Prolonged QT associated with an overdose of trazodone." J Clin Psychiatry 68 (2007): 1309-10. [PMID: 17854263]
334	Levenson JL "Prolonged QT interval after trazodone overdose." Am J Psychiatry 156 (1999): 969-70. [PMID: 10360146]
335	Mazur A, Strasberg B, Kusniec J, Sclarovsky S "QT prolongation and polymorphous ventricular tachycardia associated with trasodone-amiodarone combination." Int J Cardiol 52 (1995): 27-9. [PMID: 8707432]
336	Product Information. Oleptro (traZODone). Labopharm Inc, Laval, AL.
337	Product Information. Valtrex (valacyclovir). Glaxo Wellcome, Research Triangle Park, NC.
338	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
339	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
340	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
341	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
342	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
343	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
344	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]

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