Details of Drug-Drug Interaction
| Drug General Information (ID: DDIC1Z374D) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Rosuvastatin | Drug Info | Magnesium hydroxide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Statins/Antihyperlipidemic Agents | Antacids/Laxatives | |||||||
| Structure | |||||||||
| Mechanism of Rosuvastatin-Magnesium hydroxide Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered gastric pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Rosuvastatin | Magnesium hydroxide | |||||||
| Mechanism | Gastric pH sensitive | Gastric alkalinizer | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Gastric pH | ||||||||
| Factor Description | The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Until further data are available, patients treated with rosuvastatin should probably avoid taking antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or pediatric oral solution) for at least two hours before and after administration of rosuvastatin. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Crestor (rosuvastatin). AstraZeneca Pharma Inc, Mississauga, ON. | ||||||||||||||||||