Drug General Information (ID: DDIBQ6RTKS)
Drug Name			Acetylsalicylic acid		Drug Info		Ticagrelor		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antiplatelet Agents
Structure

Mechanism of Acetylsalicylic acid-Ticagrelor Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Acetylsalicylic acid				Ticagrelor
Mechanism		Decrease the therapeutic efficacy of ticagrelor (high maintenance dosages of aspirin)				Ticagrelor
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Acetylsalicylic acid when combined with Ticagrelor

Recommended Action
Management		Following the initial loading dose (usually 325 mg) of aspirin, a daily maintenance dose of 75 to 100 mg is recommended by the manufacturer to be used with ticagrelor.

References
1	Nefesoglu FZ, Ayanoglu-Dulger G, Ulusoy NB, Imeryuz N "Interaction of omeprazole with enteric-coated salicylate tablets." Int J Clin Pharmacol Ther 36 (1998): 549-53. [PMID: 9799060]
2	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
3	Giraud MN, Sanduja SK, Felder TB, Illich PA, Dial EJ, Lichtenberger LM. Effect of omeprazole on the bioavailability of unmodified and phospholipid-complexed aspirin in rats. Aliment Pharmacol Ther. 1997 Oct;11(5):899-906.