Details of Drug

Drug General Information (ID: D1579)
Drug Name	Ticagrelor
Drug Type	Small molecule
Drug Synonymous	Ticagrelor; 274693-27-5; Brilique; AZD-6140; AZD6140; AZD 6140; AR-C126532XX; UNII-GLH0314RVC; [14C]-Ticagrelor; GLH0314RVC; CHEBI:68558; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPYL]AMINO]-5-(PROPYLTHIO)-3H-1,2,3-TRIAZOLO[4,5-D]PYRIMIDIN-3-YL]-5-(2-HYDROXYETHOXY)-1,2-CYCLOPENTANEDIOL; (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; Brilique; AR-C126532; Ticagrelor (USAN/INN); Brilinta/Brilique Click to Show/Hide
Disease Class	BA41-BA43: Myocardial infarction; DB61-DD30: Arterial thrombosis; DB61-GB90: Thrombosis
Therapeutic Class	Antiplatelet Agents
Structure
Structure	3D Structure		2D Structure
Formula	C23H28F2N6O4S
InChI	1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
InChIKey	OEKWJQXRCDYSHL-FNOIDJSQSA-N
Canonical SMILES	CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
External Link
	Pubchem ID	9871419
	CAS Number	274693-27-5
	CHEBI ID	68558
	TTD ID	D0WF7L
	INTEDE ID	DR1591
	VARIDT ID	DR00077

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM049 Increased risk of atrioventricular block BM050 Increased risk of bleeding BM051 Increased risk of bradycardia BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ticagrelor
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[10], [1], [77]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[10], [1], [77]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[10], [1], [77]
D1183		Opium	NA	NA	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[31], [10], [32], [1], [77], [78], [79], [80], [81], [11], [82], [83]
Affected cellular transport
	Transporter inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[38]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[10], [1], [39]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[252]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[10], [1], [264]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[265]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[1], [268]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[273]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[291]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[292]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[297]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[308]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[318]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[319]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[10], [32], [1], [353]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 137
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[10], [1], [11], [12]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[10], [1], [11], [12]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[10], [1], [11], [12]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[10], [1], [11], [12]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[10], [1], [11], [12]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[10], [1], [11], [12]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[10], [1], [11], [12]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[10], [1], [11], [12]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[10], [1], [11], [12]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[10], [1], [11], [12]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[10], [1], [11], [12]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[10], [1], [11], [12]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[10], [1], [11], [12]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[10], [1], [11], [12]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[10], [1], [11], [12]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[10], [1], [11], [12]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[10], [1], [11], [12]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[10], [1], [11], [12]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[10], [1], [11], [12]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[10], [1], [11], [12]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[10], [1], [11], [12]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[10], [1], [11], [12]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[1], [11]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1], [11]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[1], [11]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[1], [11]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[46]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1], [11]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[1], [58]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[62], [10], [1], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[62], [10], [1]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[76]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[84]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[1], [85]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[1], [11]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1], [11]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[188]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[1], [11]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1], [11], [190]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[1], [11]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1], [11]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[1], [11]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1], [11]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[192], [10], [1], [193], [194], [195], [196], [197], [198]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[199]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[1], [11]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[200]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[201]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[1], [11]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1], [11]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[202], [135]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[1], [11]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[203]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1], [11]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[1], [11]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[1], [11]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[1], [227]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1], [11]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[44], [10], [1], [231], [232], [233], [234]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[10], [1], [231]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1], [11]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[1], [11]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[1], [11]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[235]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[236], [237], [238], [239], [240], [241], [242], [243]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[1], [11]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[1], [11]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[1], [11]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[1], [11]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[244], [245]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[246]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[44], [10], [1]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[247], [248]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[251]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[1], [11]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[1], [253]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[254], [255], [256], [257]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[258]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[1], [11]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1], [11]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[259]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[1], [11]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1], [11]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1], [11]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[260]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[261]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[44], [1], [262], [263]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[1], [11]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[266]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1], [11]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[1], [11]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[270]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[272]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[274]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[1], [284]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[286]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[287], [288]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[1], [289]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1], [11]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[10], [1], [290]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[293]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1], [11]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[295]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[296]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[298]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[1], [299]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[1], [11]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[302]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[1], [11]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[1], [303]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[304]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1], [305]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[306]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[307]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[1], [11]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[297]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1], [309]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[313]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1], [36], [314]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[10], [315]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[316]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[1], [11]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [320], [321]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[1], [11]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1], [11]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[1], [11]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1], [11]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[1], [11]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1], [11]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[1], [11]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[339]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[340], [341], [342], [343], [344], [345], [346]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[351]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[352]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[354]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[355]
	CYP450 enzyme induction					Drug Num: 52
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[11], [14]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[11], [14]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[11], [14]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[11], [14]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[11], [14]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[11], [14]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[24], [11], [14]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[11], [14]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[11], [14]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[11], [14]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[11], [14]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[24], [11], [14]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1], [11], [45]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1], [11], [45]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [267]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[10], [269]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[271]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[10], [294]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[44], [1], [11], [14], [45]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1], [11], [45]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [317]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[44], [1], [11], [14], [45]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[44], [1], [11], [14], [45]
Pharmacodynamic additive effects
	Increased risk of atrioventricular block					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Minor		Inter Info	[1], [11]
D0025		Adenosine	C10H13N5O4	60961	Minor		Inter Info	[1], [11]
D0069		Amlodipine	C20H25ClN2O5	2162	Minor		Inter Info	[1], [11]
D0117		Atenolol	C14H22N2O3	2249	Minor		Inter Info	[1], [11]
D0173		Betaxolol	C18H29NO3	2369	Minor		Inter Info	[1], [11]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Minor		Inter Info	[1], [11]
D0188		Bisoprolol	C18H31NO4	2405	Minor		Inter Info	[1], [11]
D0265		Carteolol	C16H24N2O3	2583	Minor		Inter Info	[1], [11]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Minor		Inter Info	[1], [11]
D0267		Carvedilol	C24H26N2O4	2585	Minor		Inter Info	[1], [11]
D0352		Clevidipine	C21H23Cl2NO6	153994	Minor		Inter Info	[1], [11]
D0602		Esmolol	C16H25NO4	59768	Minor		Inter Info	[1], [11]
D0640		Felodipine	C18H19Cl2NO4	3333	Minor		Inter Info	[1], [11]
D0865		Isradipine	C19H21N3O5	3784	Minor		Inter Info	[1], [11]
D0884		Labetalol	C19H24N2O3	3869	Minor		Inter Info	[1], [11]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Minor		Inter Info	[1], [11]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Minor		Inter Info	[1], [11]
D1049		Metoprolol	C15H25NO3	4171	Minor		Inter Info	[1], [11]
D1098		Nadolol	C17H27NO4	39147	Minor		Inter Info	[1], [11]
D1114		Nebivolol	C22H25F2NO4	71301	Minor		Inter Info	[1], [11]
D1130		Nicardipine	C26H29N3O6	4474	Minor		Inter Info	[1], [11]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[1], [11]
D1138		Nimodipine	C21H26N2O7	4497	Minor		Inter Info	[1], [11]
D1141		Nisoldipine	C20H24N2O6	4499	Minor		Inter Info	[1], [11]
D1244		Penbutolol	C18H29NO2	37464	Minor		Inter Info	[1], [11]
D1293		Pindolol	C14H20N2O2	4828	Minor		Inter Info	[1], [11]
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[1], [11]
D1498		Sotalol	C12H20N2O3S	5253	Minor		Inter Info	[1], [11]
D0661		Fingolimod	C19H33NO2	107970	Minor		Inter Info	[1], [11]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Minor		Inter Info	[1], [11]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Minor		Inter Info	[1], [11]
D1474		Siponimod	C29H35F3N2O3	44599207	Minor		Inter Info	[1], [11]
D1585		Timolol	C13H24N4O3S	33624	Minor		Inter Info	[1], [11]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Minor		Inter Info	[1], [11]
	Increased risk of bleeding					Drug Num: 138
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1], [2]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[10], [1], [13]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0415		Danaparoid	NA	NA	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[15]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[16], [17]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[1], [18]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[19]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[20], [21]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[16], [22]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[23]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[25]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[26]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1], [27]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[28]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[29]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[30]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[31], [32], [1], [33]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1], [16], [34]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[35]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[1], [36], [37]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[16]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[40]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[10], [1], [41]
D0005		Abciximab	NA	NA	Moderate		Inter Info	[1], [11]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[1], [11]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[1], [11]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[1], [11]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[1], [11]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[1], [11]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[47], [10], [1], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[1], [11]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[1], [11]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[1], [11]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[59], [60], [61]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[86]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1], [11]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[1], [11]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[189]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[16], [191]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[1], [11]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[59], [60], [61]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[59], [60], [61]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[1], [11]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[1], [11]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[1], [11]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[1], [11]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[1], [11]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[1], [11]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[1], [11]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[1], [11]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[59], [60], [61]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[223], [211], [212], [224], [213], [225], [217], [221], [226]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[228]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[1], [11]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[1], [11]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[1], [11]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[1], [229], [230]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[1], [11]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[1], [11]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[1], [11]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[1], [11]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[59], [60], [61]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[1], [11]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[1], [11]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[1], [11]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[1], [11]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[1], [11]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[1], [11]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[59], [60], [61]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[1], [11]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[47], [10], [1], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[16], [249]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[44], [250]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1], [11]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[1], [11]
D1305		Plicamycin	C52H76O24	163659	Moderate		Inter Info	[1], [11]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[1], [11]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[1], [11]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[86]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[1], [11]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[1], [11]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[1], [11]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1], [11]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[1], [11]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[59], [60], [61]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[1], [11]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[1], [11]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[1], [11]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[47], [10], [1], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[1], [11]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[1], [11]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1], [11]
D0711		Garlic	NA	NA	Moderate		Inter Info	[275], [276], [208], [211], [277], [212], [213], [278], [279], [217], [280], [281], [221], [282], [283]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[212], [215], [285], [217], [221]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[300]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[1], [301]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[1], [229], [230]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[1], [11]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[1], [11]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[310], [311], [312]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[1], [11]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[1], [11]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[1], [11]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[1], [11]
D1613		Tositumomab	NA	NA	Moderate		Inter Info	[1], [11]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[1], [11]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[1], [11]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[1], [11]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[86]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[150], [151], [152], [153], [10], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[310], [324], [1], [325], [326], [327], [328], [212], [329], [330], [331], [332], [333], [334], [335], [311], [336], [337], [312], [338]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1], [11]
D0253		Capsicum	NA	NA	Minor		Inter Info	[212]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[212], [347], [217]
D0368		Clove	NA	NA	Minor		Inter Info	[212], [348], [349], [350]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[356], [212], [357]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[42], [11], [43]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[322], [323]

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136	Product Information. Zocor (simvastatin). Merck & Co, Inc, West Point, PA.
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172	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
173	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
174	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
175	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
176	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
177	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
178	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
179	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
180	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
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202	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
203	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
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228	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.
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234	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
235	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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245	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
246	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
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248	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
249	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
250	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
251	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
252	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
253	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
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255	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
256	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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258	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
259	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
260	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
261	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
262	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
263	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
264	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
265	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
266	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
267	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
268	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
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270	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
271	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
272	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
273	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
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354	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
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