Drug General Information (ID: DDIBGQ1L6Y)
Drug Name			Ethinylestradiol		Drug Info		Glecaprevir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Estrogens				Antiviral Agents
Structure

Mechanism of Ethinylestradiol-Glecaprevir Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ethinylestradiol				Glecaprevir
Mechanism		Increases the risk of elevated alanine aminotransferase in combination with glecaprevir				Glecaprevir
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Glecaprevir and Ethinylestradiol

Recommended Action
Management		Concomitant use of ethinyl estradiol-containing medications with glecaprevir-pibrentasvir is not recommended and is considered contraindicated by some authorities.

References
1	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
2	Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]