Drug General Information (ID: DDIAXYEFJ8)
Drug Name			Isotretinoin		Drug Info		Deflazacort		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiacne Agents/Antineoplastics				Glucocorticoids
Structure

Mechanism of Isotretinoin-Deflazacort Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Isotretinoin				Deflazacort
Mechanism		Decreased bone mineral density				Decreased bone mineral density
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Isotretinoin and Deflazacort

Recommended Action
Management		Caution is advised when isotretinoin is used in combination with corticosteroids, particularly in patients with a history of osteomalacia, osteoporosis, or other disorders of bone metabolism. Bone-related laboratory and radiological tests should be considered.

References
1	Ledford D, Apter A, Brenner AM, Rubin K, Prestwood K, Frieri M, Lukert B "Osteoporosis in the corticosteroid-treated patient with asthma." J Allergy Clin Immunol 102 (1998): 353-62
2	Anderton JM, Helm R "Multiple joint osteonecrosis following short-term steroid therapy. Case report." J Bone Joint Surg Am 64 (1982): 139-41
3	Taylor LJ "Multifocal avascular necrosis after short-term high-dose steroid therapy. A report of three cases." J Bone Joint Surg Br 66 (1984): 431-3