Drug General Information (ID: DDIAV7MXYW)
Drug Name			Mecamylamine		Drug Info		Pentoxifylline		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Vasodilator Agents
Structure

Mechanism of Mecamylamine-Pentoxifylline Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Mecamylamine				Pentoxifylline
Mechanism 1		Hypotensive effects Neuronal acetylcholine receptor  Antagonist				Antihypertensive agent
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Mecamylamine and Pentoxifylline
Mechanism 2		Hypotensive effects Neuronal acetylcholine receptor  Antagonist				Hypotensive effects
Key Mechanism Factor 2
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Mecamylamine and Pentoxifylline

Recommended Action
Management		Caution is advised if pentoxifylline is used in combination with hypotensive agents. Periodic systemic blood pressure monitoring is recommended.

References
1	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.