Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIAMUICKH)
  Drug Name Valsartan Drug Info Pentoxifylline Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Vasodilator Agents
  Structure

 Mechanism of Valsartan-Pentoxifylline Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Valsartan Pentoxifylline
      Mechanism 1 Antihypertensive agent
Amiloride-sensitive sodium channel  Blocker 		Antihypertensive agent
      Key Mechanism Factor 1
Factor Name Amiloride-sensitive sodium channel Structure Sequence
Protein Family Amiloride-sensitive sodium channel (TC 1.A.6) family
Protein Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Valsartan and Pentoxifylline 
      Mechanism 2 Antihypertensive agent
Amiloride-sensitive sodium channel  Blocker 		Hypotensive effects
      Key Mechanism Factor 2
Factor Name Amiloride-sensitive sodium channel Structure Sequence
Protein Family Amiloride-sensitive sodium channel (TC 1.A.6) family
Protein Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Valsartan and Pentoxifylline 

Recommended Action
      Management Caution is advised if pentoxifylline is used in combination with hypotensive agents. Periodic systemic blood pressure monitoring is recommended.

References
1 Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.